ReviewHuman gene therapy. Clinical development2015
Dog models for blinding inherited retinal dystrophies.
Review in Human gene therapy. Clinical development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed.
- Oculodermal melanocytosis (Nevus of Ota) in a Great Dane with concurrent ocular abnormalities: a case report.Veterinary research communications · 2026Article
- Consensus guidelines for nomenclature of companion animal inherited retinal disorders.Veterinary ophthalmology · 2025Article
- A diffusion tensor imaging white matter atlas of the domestic canine brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Gene augmentation therapy attenuates retinal degeneration in a knockout mouse model of Fam161a retinitis pigmentosa.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Translatability barriers between preclinical and clinical trials of AAV gene therapy in inherited retinal diseases.Vision research · 2023Review
- Article
- Subjective vision assessment in companion dogs using dogVLQ demonstrates age-associated visual dysfunction.Frontiers in veterinary science · 2023Article
- Characterization of scotopic and mesopic rod signaling pathways in dogs using the On-Off electroretinogram.BMC veterinary research · 2022Article
- Quantitative and qualitative characterization of retinal dystrophies in canine models of inherited retinal diseases using spectral domain optical coherence tomography (SD-OCT).Experimental eye research · 2022Article
- Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series.BMC veterinary research · 2022Article
- On the importance of integrating comparative anatomy and One Health perspectives in anatomy education.Journal of anatomy · 2022Review
- Development of retinal bullae in dogs with progressive retinal atrophy.Veterinary ophthalmology · 2022Article
- ERG assessment of altered retinal function in canine models of retinitis pigmentosa and monitoring of response to translatable gene augmentation therapy.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- An ERG and OCT study of neuronal ceroid lipofuscinosis CLN2 Battens retinopathy.Eye (London, England) · 2021Article
- Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model.Journal of visualized experiments : JoVE · 2021Article
- A modified silent substitution electroretinography protocol to separate photoreceptor subclass function in lightly sedated dogs.Veterinary ophthalmology · 2021Article
- Noise-Induced Hearing Loss and its Prevention: Current Issues in Mammalian Hearing.Current opinion in physiology · 2020Article
- A LINE-1 insertion situated in the promoter of IMPG2 is associated with autosomal recessive progressive retinal atrophy in Lhasa Apso dogs.BMC genetics · 2020Article
- Electroretinogram of the Cone-Dominant Thirteen-Lined Ground Squirrel during Euthermia and Hibernation in Comparison with the Rod-Dominant Brown Norway Rat.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Spontaneous canine models exist for several inherited retinal dystrophies. This review will summarize the models and indicate where they have been used in translational gene therapy trials. The RPE65 gene therapy trials to treat childhood blindness are a good example of how studies in dogs have contributed to therapy development. Outcomes in human clinical trials are compared and contrasted with the result of the preclinical dog trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.