ArticleMolecules (Basel, Switzerland)2015
Solvent-free copper-catalyzed azide-alkyne cycloaddition under mechanochemical activation.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Mechanochemically Synthesized Amidetriazoles for Effective Optical and Electrochemical Detection of Anions.The Journal of organic chemistry · 2026Article
- Mechanochemical Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC).The Journal of organic chemistry · 2026Review
- Mechano-Induced Synthesis of Polyethylene Glycols α,ω-DiSubstituted with 4-(PAH)-1Molecules (Basel, Switzerland) · 2026Article
- Mechanochemical Aerobic Activation of Metallic Copper for the Synthesis of 1,4-Allenynes.ChemSusChem · 2025Article
- Copper(i)-catalyzed click chemistry in deep eutectic solvent for the syntheses of β-d-glucopyranosyltriazoles.RSC advances · 2023Article
- Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives.Molecules (Basel, Switzerland) · 2023Review
- Investigation of 1,4-Substituted 1,2,3-Triazole Derivatives as Antiarrhythmics: Synthesis, Structure, and Properties.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Mechanochemical Approach towards Multi-Functionalized 1,2,3-Triazoles and Anti-Seizure Drug Rufinamide Analogs Using Copper Beads.Molecules (Basel, Switzerland) · 2022Article
- The Direct Mechanocatalytic Suzuki-Miyaura Reaction of Small Organic Molecules.Angewandte Chemie (International ed. in English) · 2022Article
- Mono-6-Substituted Cyclodextrins-Synthesis and Applications.Molecules (Basel, Switzerland) · 2021Review
- Direct Mechanocatalysis: Using Milling Balls as Catalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Review
- Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions.RSC advances · 2019Article
- Electrolytic copper as cheap and effective catalyst for one-pot triazole synthesis.Scientific reports · 2018Article
- Azide-alkyne cycloaddition reactions in waterRSC advances · 2018Article
- Solvent-free copper-catalyzed click chemistry for the synthesis ofBeilstein journal of organic chemistry · 2017Article
- Enabling technologies and green processes in cyclodextrin chemistry.Beilstein journal of organic chemistry · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ball-mill-based mechanochemical activation of metallic copper powder facilitates solvent-free alkyne-azide click reactions (CuAAC). All parameters that affect reaction rate (i.e., milling time, revolutions/min, size and milling ball number) have been optimized. This new, efficient, facile and eco-friendly procedure has been tested on a number of different substrates and in all cases afforded the corresponding 1,4-disubstituted 1,2,3-triazole derivatives in high yields and purities. The final compounds were isolated in almost quantitative overall yields after simple filtration, making this procedure facile and rapid. The optimized CuAAC protocol was efficiently applied even with bulky functionalized β-cyclodextrins (β-CD) and scaled-up to 10 g of isolated product.
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