ArticleOncotarget2015
Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- PCA-based synthetic sensitivity coefficients for chemical reaction network in cancer.Scientific reports · 2024Article
- Article
- Deep Hidden Physics Modeling of Cell Signaling Networks.Current genomics · 2021Article
- Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells.Scientific reports · 2021Article
- The status of causality in biological databases: data resources and data retrieval possibilities to support logical modeling.Briefings in bioinformatics · 2021Article
- Gain and loss of function mutations in biological chemical reaction networks: a mathematical model with application to colorectal cancer cells.Journal of mathematical biology · 2021Article
- Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers.Communications biology · 2018Article
- Modelling the molecular mechanisms of aging.Bioscience reports · 2017Review
- Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance.Genome medicine · 2017Article
- Wnt signalling is a bi-directional vulnerability of cancer cells.Oncotarget · 2016Article
- Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis.Journal of cellular physiology · 2015Article
- Principles for Developing Patient Avatars in Precision and Systems Medicine.Frontiers in genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interconnected network of pathways downstream of the TGFβ, WNT and EGF-families of receptor ligands play an important role in colorectal cancer pathogenesis.We studied and implemented dynamic simulations of multiple downstream pathways and described the section of the signaling network considered as a Molecular Interaction Map (MIM). Our simulations used Ordinary Differential Equations (ODEs), which involved 447 reactants and their interactions.Starting from an initial "physiologic condition", the model can be adapted to simulate individual pathologic cancer conditions implementing alterations/mutations in relevant onco-proteins. We verified some salient model predictions using the mutated colorectal cancer lines HCT116 and HT29. We measured the amount of MYC and CCND1 mRNAs and AKT and ERK phosphorylated proteins, in response to individual or combination onco-protein inhibitor treatments. Experimental and simulation results were well correlated. Recent independently published results were also predicted by our model.Even in the presence of an approximate and incomplete signaling network information, a predictive dynamic modeling seems already possible. An important long term road seems to be open and can be pursued further, by incremental steps, toward even larger and better parameterized MIMs. Personalized treatment strategies with rational associations of signaling-proteins inhibitors, could become a realistic goal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.