ArticleJournal of exercise nutrition & biochemistry2014
Effect of exercise on hyperactivity, impulsivity and dopamine D2 receptor expression in the substantia nigra and striatum of spontaneous hypertensive rats.
Article in Journal of exercise nutrition & biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Vagal sensing of altered gut microbiota links to externalizing behaviors.Gut microbes · 2026Article
- ADHD Symptoms and Cannabis Use: The Role of Cannabinoid Receptor 1 and Neural Response Inhibition.medRxiv : the preprint server for health sciences · 2026Article
- Abscisic Acid Rescues Behavior in Adult Female Mice in Attention Deficit Disorder with Hyperactivity Model of Dopamine Depletion by Regulating Microglia and Increasing Vesicular GABA Transporter Expression.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Current Perspectives on Attention-deficit Hyperactivity Disorder.Current molecular medicine · 2025Review
- Selenoprotein P in a Rodent Model of Exercise; Theorizing Its Interaction with Brain Reward Dysregulation, Addictive Behavior, and Aging.Journal of personalized medicine · 2024Article
- Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats.International journal of molecular sciences · 2024Article
- The co-use of nicotine and prescription psychostimulants: A review of their behavioral and neuropharmacological interactions.Drug and alcohol dependence · 2023Review
- Serotonin and Dopamine Blood Levels in ADHD-Like Dogs.Animals : an open access journal from MDPI · 2023Article
- High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling.Frontiers in public health · 2023Article
- Risk-taking in traffic is associated with unhealthy lifestyle: Contribution of aggressiveness and the serotonin transporter genotype.Neuroscience applied · 2022Article
- Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward.The Journal of clinical investigation · 2021Article
- Stability of Methylphenidate under Various pH Conditions in the Presence or Absence of Gut Microbiota.Pharmaceuticals (Basel, Switzerland) · 2021Article
- The German Three Factor Impulsivity Index: Confirmatory factor analysis and ties to demographic and health-related variables.Personality and individual differences · 2021Article
- Decreased Plasma Levels of Angiotensin-Converting Enzyme Among Patients With Bipolar Disorder.Frontiers in neuroscience · 2021Article
- Effects of Exercise on Cognitive Performance in Children and Adolescents with ADHD: Potential Mechanisms and Evidence-based Recommendations.Journal of clinical medicine · 2019Review
- The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.Frontiers in psychiatry · 2017Review
- Evidence-Based Considerations and Recommendations for Athletic Trainers Caring for Patients With Attention-Deficit/Hyperactivity Disorder.Journal of athletic training · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAttention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurobehavioral disorder that is characterized by hyperactivity, inattention, and impulsivity. It is commonly believed that the symptoms of ADHD are closely associated with hypo-function of the dopamine system. Dopamine D2 receptor activation decreases the excitability of dopamine neurons, as well as the release of dopamine. Physical exercise is known to improve structural and functional impairments in neuropsychiatric disorders. We investigated the therapeutic effect of exercise on ADHD.
methodsOpen field task and elevated-plus maze task were used in the evaluation of hyperactivity and impulsivity, respectively. Dopamine D2 receptor expression in the substantia nigra and striatum were evaluated by western blotting.
resultsThe present results indicated that ADHD rats showed hyperactivity and impulsivity. Dopamine D2 receptor expression in the substantia nigra and striatum were increased in ADHD rats. Exercise alleviated hyperactivity and impulsivity in ADHD rats. Furthermore, dopamine D2 receptor expression in ADHD rats was also decreased by exercise.
conclusionWe thus showed that exercise effectively alleviates ADHD-induced symptoms through enhancing dopamine D2 expression in the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.