ArticleBeilstein journal of nanotechnology2015
Oxygen-plasma-modified biomimetic nanofibrous scaffolds for enhanced compatibility of cardiovascular implants.
Article in Beilstein journal of nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
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- Mitomycin C-immobilized silver nanoparticle-loaded polycaprolactone membrane for temporary scalp expansion after decompressive craniectomy to prevent wound infection.Bioengineering & translational medicine · 2025Article
- Preparation and Microscopic Mechanical Characterization of L-Methionine-Based Polyphosphazene Fibrous Mats for Vascular Tissue Engineering.Pharmaceutics · 2023Article
- Current Trends in Biomedical Hydrogels: From Traditional Crosslinking to Plasma-Assisted Synthesis.Polymers · 2022Review
- Nanofibrous materials affect the reaction of cytotoxicity assays.Scientific reports · 2022Article
- Decorating 3D Printed Scaffolds with Electrospun Nanofiber Segments for Tissue Engineering.Advanced biosystems · 2019Article
- Intrinsic Cellular Responses of Human Wharton's Jelly Mesenchymal Stem Cells Influenced by OJournal of functional biomaterials · 2019Article
- Time-of-flight secondary ion mass spectrometry three-dimensional imaging of surface modifications in poly(caprolactone) scaffold pores.Journal of biomedical materials research. Part A · 2019Article
- Fabrication and Characterization of Bioresorbable Drug-coated Porous Scaffolds for Vascular Tissue Engineering.Materials (Basel, Switzerland) · 2019Article
- Hybrid polycaprolactone/hydrogel scaffold fabrication and in-process plasma treatment using PABS.International journal of bioprinting · 2019Article
- Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation.RSC advances · 2018Article
- The Enhanced Lithium-Storage Performance for MnO Nanoparticles Anchored on Electrospun Nitrogen-Doped Carbon Fibers.Nanomaterials (Basel, Switzerland) · 2018Article
- Argon plasma improves the tissue integration and angiogenesis of subcutaneous implants by modifying surface chemistry and topography.International journal of nanomedicine · 2018Article
- A General Strategy for Generating Gradients of Bioactive Proteins on Electrospun Nanofiber Mats by Masking with Bovine Serum Albumin.Journal of materials chemistry. B · 2017Article
- Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering.Chemical communications (Cambridge, England) · 2017Article
- Atomic Force Microscopy: A Powerful Tool to Address Scaffold Design in Tissue Engineering.Journal of functional biomaterials · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrospun nanofibrous scaffolds have been extensively used in several biomedical applications for tissue engineering due to their morphological resemblance to the extracellular matrix (ECM). Especially, there is a need for the cardiovascular implants to exhibit a nanostructured surface that mimics the native endothelium in order to promote endothelialization and to reduce the complications of thrombosis and implant failure. Thus, we herein fabricated poly-ε-caprolactone (PCL) electrospun nanofibrous scaffolds, to serve as coatings for cardiovascular implants and guide tissue regeneration. Oxygen plasma treatment was applied in order to modify the surface chemistry of the scaffold and its effect on cell attachment and growth was evaluated. The conditions of the surface modification were properly adjusted in order to define those conditions of the treatment that result in surfaces favorable for cell growth, while maintaining morphological integrity and mechanical behavior. Goniometry (contact angle measurements), scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS) measurements were used to evaluate the morphological and chemical changes induced by the plasma treatment. Moreover, depth-sensing nanoindentation was performed to study the resistance of the plasma-treated scaffolds to plastic deformation. Lastly, the cell studies indicated that all scaffolds were cytocompatible, with the plasma-treated ones expressing a more pronounced cell viability and adhesion. All the above findings demonstrate the great potential of these biomimetic tissue-engineering constructs as efficient coatings for enhanced compatibility of cardiovascular implants.
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