ArticleTranslational neurodegeneration2014
Prevalence of wearing-off and dyskinesia among the patients with Parkinson's disease on levodopa therapy: a multi-center registry survey in mainland China.
Article in Translational neurodegeneration, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Trial
- Long-term safety and efficacy of adjunctive rasagiline in levodopa-treated Japanese patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2019Trial
- Frequency and types of motor fluctuations in patients presenting with advanced Parkinson's disease.Pakistan journal of medical sciences · 2026Article
- Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs.Movement disorders clinical practice · 2026Article
- Mechanism of the protective effect of 2,3,5,4'-Tetrahydroxy stilbene-2-O-β-D-glucoside on MPTP-induced Parkinson's disease mice.Histology and histopathology · 2026Article
- Identifying Risk Factors and Constructing Predictive Models for Wearing-Off and Dyskinesia in Chinese Patients With Parkinson's Disease on Long-Term Levodopa Therapy.CNS neuroscience & therapeutics · 2025Article
- Safinamide as an Adjunct to Levodopa in Asian and Caucasian Patients With Parkinson's Disease and Motor Fluctuations: A Post Hoc Analysis of the SETTLE Study.Journal of movement disorders · 2023Article
- Identification and quantitative assessment of motor complications in Parkinson's disease using the Parkinson's KinetiGraph™.Frontiers in aging neuroscience · 2023Article
- Inhaled Levodopa (CVT-301) for the Treatment of Parkinson Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Neurology. Clinical practice · 2022Review
- Correlation Between Lacunae and the Wearing-off Phenomenon in Parkinson's Disease.Neuropsychiatric disease and treatment · 2022Article
- Multivariable clinical-genetic model for predicting dyskinesia in early-onset Parkinson's disease.Translational neurodegeneration · 2021Article
- Evaluation of Motor Complications in Parkinson's Disease: Understanding the Perception Gap between Patients and Physicians.Parkinson's disease · 2021Article
- Profiling the most elderly parkinson's disease patients: Does age or disease duration matter?PloS one · 2021Article
- Analysis of Motor Complication and Relative Factors in a Cohort of Chinese Patients with Parkinson's Disease.Parkinson's disease · 2020Article
- Risk thresholds of levodopa dose for dyskinesia in Chinese patients with Parkinson's disease: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Wearing-off Identification in Parkinson's Disease: The shapd-woq Study.Frontiers in neurology · 2020Article
- Factors Associated With Dyskinesia in Parkinson's Disease in Mainland China.Frontiers in neurology · 2019Article
- Parkinson's disease in China: a forty-year growing track of bedside work.Translational neurodegeneration · 2019Review
- Poor nighttime sleep is positively associated with dyskinesia in Parkinson's disease patients.Parkinsonism & related disorders · 2018Article
- Long-term treatment of Parkinson's disease with levodopa and other adjunctive drugs.Journal of neural transmission (Vienna, Austria : 1996) · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChronic levodopa (L-dopa) treatment in Parkinson's disease (PD) is often associated with the development of motor complications, but the corresponding epidemiological data is rare in Chinese PD patients. The present survey was to investigate the prevalence rate of wearing-off (WO) and dyskinesia among the patients with PD in China.
methodsFrom May 2012 to October 2012, a 3-step registry survey for wearing off (WO) and dyskinesia patients with PD receiving levodopa therapy was performed simultaneously at 28 movement disorders clinics in China.
resultsThere were 1,558 PD patients fulfilling the inclusion criteria. Among them, 1,051 had at least one positive response of 9-item wearing off questionnaire (WOQ-9), 724 and 160 patients were finally diagnosed with WO and dyskinesia by movement disorders specialists, respectively. The overall prevalence rates of WO and dyskinesia were 46.5% (95% CI 44.0% - 48.9%) and 10.3% (95% CI 8.8% - 11.8%), respectively. The mean score of WOQ-9 for those with WO was 3.8 (SD = 1.8), with movement slowness being the most common motor symptoms and pain/aching being the most common non-motor symptoms. Better improvement of motor symptoms (n = 354, 87.8%) and long-term disease control and drug selection (n = 288, 71.5%) were the two most frequently considered factors when movement disorders specialists adjusted therapeutic strategies for patients with WO.
conclusionsThis survey provided the first multi-center epidemiological data of motor complications among PD patients on L-dopa therapy from mainland China. WO prevalence rate among Chinese PD patients was in line with, while dyskinesia prevalence rate was lower than previous reports from other Countries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.