ArticleNutrition research and practice2015
Inhibitory activities of Perilla frutescens britton leaf extract against the growth, migration, and adhesion of human cancer cells.
Article in Nutrition research and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- The Antiviral Potential ofMolecules (Basel, Switzerland) · 2024Pooled it
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- Phytochemical-Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles.Phytotherapy research : PTR · 2026Review
- Comparison of Lignan Contents and Antioxidant Activities in Five Perilla (Preventive nutrition and food science · 2026Article
- The Apoptosis Induction and Immunomodulating Activities of Nga-Kee-Mon (Foods (Basel, Switzerland) · 2025Article
- Promising leads against lung cancer from the plants in Lamiaceae family.BioImpacts : BI · 2025Review
- The Role and Mechanism ofMolecules (Basel, Switzerland) · 2023Review
- Review
- Comparative transcriptome sequencing analysis to postulate the scheme of regulated leaf coloration in Perilla frutescens.Plant molecular biology · 2023Article
- The Extract ofFoods (Basel, Switzerland) · 2023Article
- Efficacy ofFrontiers in pharmacology · 2023Article
- Chemical Compositions, Extraction Optimizations, and In Vitro Bioactivities of Flavonoids from Perilla Leaves (Antioxidants (Basel, Switzerland) · 2022Article
- Article
- Two Pairs of 7,7'-Cyclolignan Enantiomers with Anti-Inflammatory Activities fromMolecules (Basel, Switzerland) · 2022Article
- Review
- Single-cell adhesivity distribution of glycocalyx digested cancer cells from high spatial resolution label-free biosensor measurements.Matrix biology plus · 2022Article
- Measures Matter-Determining the True Nutri-Physiological Value of Feed Ingredients for Swine.Animals : an open access journal from MDPI · 2021Review
- Isoegomaketone fromEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Extracts ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesPerilla frutescens Britton leaves are a commonly consumed vegetable in different Asian countries including Korea. Cancer is a major cause of human death worldwide. The aim of the current study was to investigate the inhibitory effects of ethanol extract of perilla leaf (PLE) against important characteristics of cancer cells, including unrestricted growth, resisted apoptosis, and activated metastasis, using human cancer cells. MATERIALS/
methodsTwo human cancer cell lines were used in this study, HCT116 colorectal carcinoma cells and H1299 non-small cell lung carcinoma cells. Assays using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide were performed for measurement of cell growth. Soft agar and wound healing assays were performed to determine colony formation and cell migration, respectively. Nuclear staining and cell cycle analysis were performed for assessment of apoptosis. Fibronectin-coated plates were used to determine cell adhesion.
resultsTreatment of HCT116 and H1299 cells with PLE resulted in dose-dependent inhibition of growth by 52-92% (at the concentrations of 87.5, 175, and 350 µg/ml) and completely abolished the colony formation in soft agar (at the concentration of 350 µg/ml). Treatment with PLE at the 350 µg/ml concentration resulted in change of the nucleus morphology and significantly increased sub-G1 cell population in both cells, indicating its apoptosis-inducing activity. PLE at the concentration range of 87.5 to 350 µg/ml was also effective in inhibiting the migration of H1299 cells (by 52-58%) and adhesion of both HCT116 and H1299 cells (by 25-46%).
conclusionsThese results indicate that PLE exerts anti-cancer activities against colon and lung cancers in vitro. Further studies are needed in order to determine whether similar effects are reproduced in vivo.
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Registered trials
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