Evidence map›Paper›PMID 25670947›Full record

ArticlePsychiatry investigation2015

Neural Network Based Response Prediction of rTMS in Major Depressive Disorder Using QEEG Cordance.

Turker Tekin Erguzel, Serhat Ozekes, Selahattin Gultekin, Nevzat Tarhan, Gokben Hizli Sayar, Ali Bayram

Open access · diamondAbstract read
In one paragraph

Article in Psychiatry investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Predictors of Somatic Symptom Severity in Adult Psychiatric Outpatients: A Cross-sectional Heart Rate Variability and Quantitative Electroencephalography Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
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  10. How to Solve Clinical Challenges in Mood Disorders; Machine Learning Approaches Using Electrophysiological Markers.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. The promise of machine learning in predicting treatment outcomes in psychiatry.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
    Article
  16. Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021
    Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Turker Tekin ErguzelDepartment of Computer Engineering, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul, Turkey.
Serhat OzekesDepartment of Computer Engineering, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul, Turkey.
Selahattin GultekinDepartment of Bioengineering, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul, Turkey.
Nevzat TarhanDepartment of Psychiatry, Faculty of Humanities and Social Sciences, Uskudar University, Istanbul, Turkey. ; Department of Psychiatry, NPIstanbul Hospital, Istanbul, Turkey.
Gokben Hizli SayarDepartment of Psychiatry, Faculty of Humanities and Social Sciences, Uskudar University, Istanbul, Turkey. ; Department of Psychiatry, NPIstanbul Hospital, Istanbul, Turkey.
Ali BayramBiomedical Equipment Technology, Uskudar University, Istanbul, Turkey.
Üsküdar University · TRNpistanbul Brain Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe combination of repetitive transcranial magnetic stimulation (rTMS), a non-pharmacological form of therapy for treating major depressive disorder (MDD), and electroencephalogram (EEG) is a valuable tool for investigating the functional connectivity in the brain. This study aims to explore whether pre-treating frontal quantitative EEG (QEEG) cordance is associated with response to rTMS treatment among MDD patients by using an artificial intelligence approach, artificial neural network (ANN).

methodsThe artificial neural network using pre-treatment cordance of frontal QEEG classification was carried out to identify responder or non-responder to rTMS treatment among 55 MDD subjects. The classification performance was evaluated using k-fold cross-validation.

resultsThe ANN classification identified responders to rTMS treatment with a sensitivity of 93.33%, and its overall accuracy reached to 89.09%. Area under Receiver Operating Characteristic (ROC) curve (AUC) value for responder detection using 6, 8 and 10 fold cross validation were 0.917, 0.823 and 0.894 respectively.

conclusionPotential utility of ANN approach method can be used as a clinical tool in administering rTMS therapy to a targeted group of subjects suffering from MDD. This methodology is more potentially useful to the clinician as prediction is possible using EEG data collected before this treatment process is initiated. It is worth using feature selection algorithms to raise the sensitivity and accuracy values.

Indexed as

ElectroencephalographyMajor depressive disorderNeural networkTranscranial magnetic stimulation

Identifiers

PMID25670947
PMCPMC4310922
OpenAlexW2168555712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.