ReviewTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2014
The Influence of Clinical and Biological Factors on Transfusion-Associated Non-ABO Antigen Alloimmunization: Responders, Hyper-Responders, and Non-Responders.
Review in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Distribution of extended red blood cell phenotypes among blood donors: experience from a low- and middle-income country.Scientific reports · 2026Article
- The Distribution Patterns of Rhesus (Rh) Antigens.Cureus · 2024Article
- Future prospects for the clinical transfusion of pig red blood cells.Blood reviews · 2023Review
- Phenotyping of clinically significant blood group antigens among the South Indian donor population.Hematology, transfusion and cell therapy · 2023Article
- The Development and Consequences of Red Blood Cell Alloimmunization.Annual review of pathology · 2023Review
- Article
- Following targeted routine antenatal anti-D prophylaxis, almost half of the pregnant women had undetectable anti-D prophylaxis at delivery.Acta obstetricia et gynecologica Scandinavica · 2022Observational
- Pathophysiology of Alloimmunization.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2020Article
- Red Blood Cell Alloimmunization in Korean Patients With Myelodysplastic Syndrome and Liver Cirrhosis.Annals of laboratory medicine · 2019Article
- A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease.Blood advances · 2018Article
- A Conceptual Framework for Optimizing Blood Matching Strategies: Balancing Patient Complications Against Total Costs Incurred.Frontiers in medicine · 2018Article
- Association ofTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018Article
- Red blood cell minor antigen mismatches during chronic transfusion therapy for sickle cell anemia.Transfusion · 2017Article
- Medical and economic implications of strategies to prevent alloimmunization in sickle cell disease.Transfusion · 2017Review
- Impact of azacitidine on red blood cell alloimmunisation in myelodysplastic syndrome.Blood transfusion = Trasfusione del sangue · 2017Article
- Chronic inflammatory autoimmune disorders are a risk factor for red blood cell alloimmunization.British journal of haematology · 2016Article
- Responder individuality in red blood cell alloimmunization.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2014Article
- Prevalence and specificity of red blood cell alloantibodies and autoantibodies in transfused Iranian β-thalassemia patients: A systematic review and meta-analysis.Asian journal of transfusion scienceReview
- Impact of antigenic exposures and role of molecular blood grouping in enhancing transfusion safety in chronically transfused thalassemics.Asian journal of transfusion scienceArticle
- "When less is more and more is less" red cell alloimmunization in multitransfused patients attending a medical institution with a newly developed blood center in North India: A multifactorial study.Asian journal of transfusion scienceArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the context of transfusion medicine, alloimmunization most often refers to the development of antibodies to non-ABO red blood cell (RBC) antigens following pregnancy, transfusion, or transplantation. The development of RBC alloantibodies can have important clinical consequences, particularly in patients who require chronic transfusions. It has been suggested that alloimmunization is more common in some clinical circumstances and patient populations than in others. As such, individuals that develop alloantibodies are frequently referred to as 'responders' in the medical literature. In contrast, individuals that do not develop alloantibodies despite repeated exposures to non-self blood group antigens have been referred to as 'non-responders'. The purpose of this article is to review the phenomenon of RBC alloimmunization in the context of responders and non-responders to: i) establish a basic framework for alloimmunization as reported across several diverse patient populations; ii) more fully explore literature reports which support the concept of responders/non-responders regarding blood group antigen alloimmunization; iii) summarize the mechanisms that have been shown to predispose an individual to alloimmunization to determine how these factors may differentiate 'responders' from 'non-responders'; and iv) briefly discuss some practical approaches to prevent alloimmunization in patients who may be prone to alloantibody development.
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