ArticleClinical interventions in aging2015
Joint unloading implant modifies subchondral bone trabecular structure in medial knee osteoarthritis: 2-year outcomes of a pilot study using fractal signature analysis.
Article in Clinical interventions in aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Implantable Shock Absorber: Breakthrough or Hype?Current reviews in musculoskeletal medicine · 2026Review
- Subchondral bone in knee osteoarthritis: bystander or treatment target?Skeletal radiology · 2023Review
- Preliminary biomechanical cadaver study investigating a new load-sharing knee implant.Journal of experimental orthopaedics · 2021Article
- Trabecular bone texture analysis of conventional radiographs in the assessment of knee osteoarthritis: review and viewpoint.Arthritis research & therapy · 2021Review
- Quantitative imaging of bone remodeling in patients with a unicompartmental joint unloading knee implant (ATLAS Knee System)-effect of metal artifacts on a SPECT-CT-based quantification.EJNMMI physics · 2021Article
- Can UKA after KineSpring system failure be a viable option? A case report.Acta bio-medica : Atenei Parmensis · 2019Article
- Two-Year Results of the PHANTOM High Flex Trial: A Single-Arm Study on the Atlas Unicompartmental Knee System Load Absorber in Patients With Medial Compartment Osteoarthritis of the Knee.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2019Article
- Models to define the stages of articular cartilage degradation in osteoarthritis development.International journal of experimental pathology · 2017Review
- Feasibility of the Atlas Unicompartmental Knee System Load Absorber in Improving Pain Relief and Function in Patients Needing Unloading of the Medial Compartment of the Knee: 1-Year Follow-Up of a Prospective, Multicenter, Single-Arm Pilot Study (PHANTOM High Flex Trial).Clinical medicine insights. Arthritis and musculoskeletal disorders · 2017Article
- Load distribution in early osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Review
- Safety and Feasibility of a KineSpring Knee System for the Treatment of Osteoarthritis: A Case Series.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnee osteoarthritis (OA) is largely attributable to chronic excessive and aberrant joint loading. The purpose of this pilot study was to quantify radiographic changes in subchondral bone after treatment with a minimally invasive joint unloading implant (KineSpring(®) Knee Implant System).
methodsNine patients with unilateral medial knee OA resistant to nonsurgical therapy were treated with the KineSpring System and followed for 2 years. Main outcomes included Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, and stiffness subscores and independent core laboratory determinations of joint space width and fractal signature of the tibial cortex.
resultsWOMAC scores, on average, improved by 92% for pain, 91% for function, and 79% for stiffness over the 2-year follow-up period. Joint space width in the medial compartment of the treated knee significantly increased from 0.9 mm at baseline to 3.1 mm at 2 years; joint space width in the medial compartment of the untreated knee was unchanged. Fractal signatures of the vertically oriented trabeculae in the medial compartment decreased by 2.8% in the treated knee and increased by 2.1% in the untreated knee over 2 years. No statistically significant fractal signature changes were observed in the horizontally oriented trabeculae in the medial compartment or in the horizontal or vertical trabeculae of the lateral compartment in the treated knee.
conclusionPreliminary evidence suggests that the KineSpring System may modify knee OA disease progression by increasing joint space width and improving subchondral bone trabecular integrity, thereby reducing pain and improving joint function.
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