ArticlePlant physiology2015
Reducing the genetic redundancy of Arabidopsis PHOSPHATE TRANSPORTER1 transporters to study phosphate uptake and signaling.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69 citing papers in PubMed.
- Transporter promiscuity and redox-driven metal partitioning in plant responses to chemically analogous metals.Plant cell reports · 2026Review
- Genome-wide identification of phosphate transporter gene family in Trichoderma harzianum and expression in response to biotic and abiotic stress.Scientific reports · 2026Article
- Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings.Plant, cell & environment · 2026Article
- Genome-wide analysis of the phosphate transporter gene family in oats: insights into phosphorus and water deficiency responses.Journal of applied genetics · 2026Article
- Identification of the phosphate transporter 1 family genes in the Eucalyptus grandis genome and their expression under different phosphate regimes.BMC genomics · 2026Article
- Silencing of the Mycorrhiza-Inducible Phosphate TransporterPlants (Basel, Switzerland) · 2026Article
- MmPHR1 enhances low phosphorus stress tolerance by activating MmPHT1;5 in an elite apple rootstock -Malus mandshurica.BMC plant biology · 2025Article
- Decoding PHR-Orchestrated Stress Adaptation: A Genome-Wide Integrative Analysis of Transcriptional Regulation Under Abiotic Stress inInternational journal of molecular sciences · 2025Article
- Weighted Gene Correlation Network Analysis Reveals Key Regulatory Genes Influencing Selenium Enrichment and Yield with Exogenous Selenite in Tartary Buckwheat.Plants (Basel, Switzerland) · 2025Article
- The AP2/ERF Transcription Factor ERF56 Negatively Regulating Nitrate-Dependent Plant Growth inInternational journal of molecular sciences · 2025Article
- From genes to traits: maximizing phosphorus utilization efficiency in crop plants.Frontiers in plant science · 2025Review
- Epigenetic odyssey to decrypt the hidden code for sustainable brassica production: enhancing yield, stress resilience and nutritional quality.Frontiers in plant science · 2025Review
- Adaptation of potato cultivars to phosphorus variability and enhancement of phosphorus efficiency by Bacillus subtilis.BMC plant biology · 2024Article
- Defense-related callose synthase PMR4 promotes root hair callose deposition and adaptation to phosphate deficiency in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2024Article
- Evolution of phosphate scouting in the terrestrial biosphere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- MicroRNAs as potent regulators in nitrogen and phosphorus signaling transduction and their applications.Stress biology · 2024Review
- Article
- Milestones in understanding transport, sensing, and signaling of the plant nutrient phosphorus.The Plant cell · 2024Review
- Traits linked to natural variation of sulfur content in Arabidopsis thaliana.Journal of experimental botany · 2024Article
- Visualizing plant intracellular inorganic orthophosphate distribution.Nature plants · 2024Article
9 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Arabidopsis (Arabidopsis thaliana) absorbs inorganic phosphate (Pi) from the soil through an active transport process mediated by the nine members of the PHOSPHATE TRANSPORTER1 (PHT1) family. These proteins share a high level of similarity (greater than 61%), with overlapping expression patterns. The resulting genetic and functional redundancy prevents the analysis of their specific roles. To overcome this difficulty, our approach combined several mutations with gene silencing to inactivate multiple members of the PHT1 family, including a cluster of genes localized on chromosome 5 (PHT1;1, PHT1;2, and PHT1;3). Physiological analyses of these lines established that these three genes, along with PHT1;4, are the main contributors to Pi uptake. Furthermore, PHT1;1 plays an important role in translocation from roots to leaves in high phosphate conditions. These genetic tools also revealed that some PHT1 transporters likely exhibit a dual affinity for phosphate, suggesting that their activity is posttranslationally controlled. These lines display significant phosphate deficiency-related phenotypes (e.g. biomass and yield) due to a massive (80%-96%) reduction in phosphate uptake activities. These defects limited the amount of internal Pi pool, inducing compensatory mechanisms triggered by the systemic Pi starvation response. Such reactions have been uncoupled from PHT1 activity, suggesting that systemic Pi sensing is most probably acting downstream of PHT1.
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