Evidence map›Paper›PMID 25670789›Full record

ReviewDevelopment (Cambridge, England)2015

The melanocyte lineage in development and disease.

Richard L Mort, Ian J Jackson, E Elizabeth Patton

Erratum issuedOpen access · hybridAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 176 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 1 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 1 synthesis or guideline pooled it, 395 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Transcriptomic Analysis IdentifiesAnimals : an open access journal from MDPI · 2026
    Article
  5. Skin Cancer Recognition and Education Among Community Health Workers in Southern New Mexico.International journal of environmental research and public health · 2026
    Article
  6. Bacterioruberin fromInternational journal of molecular sciences · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Cell type diversification and phenotype convergence underlying white fin-ornamentation of cyprinid fishes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Exploring the immune landscape of melanoma of the lower female genital tract.Virchows Archiv : an international journal of pathology · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Defining the role of integrins in melanoblast migrationMolecular biology of the cell · 2025
    Article
  20. Review

116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Richard L MortMRC Human Genetics Unit and.
Ian J JacksonMRC Human Genetics Unit and University of Edinburgh Cancer Research UK Cancer Centre, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK ian.jackson@igmm.ed.ac.uk.
E Elizabeth PattonMRC Human Genetics Unit and Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK.
Edinburgh Cancer Research · GBMRC Human Genetics UnitUniversity of Edinburgh · GB

Funding

Medical Research Council MC_PC_U127527200Medical Research Council MC_PC_U127561112Medical Research Council MC_PC_U127585840Medical Research Council MC_U127585840National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K001612/1
6 · The paper itself

Abstract

Melanocyte development provides an excellent model for studying more complex developmental processes. Melanocytes have an apparently simple aetiology, differentiating from the neural crest and migrating through the developing embryo to specific locations within the skin and hair follicles, and to other sites in the body. The study of pigmentation mutations in the mouse provided the initial key to identifying the genes and proteins involved in melanocyte development. In addition, work on chicken has provided important embryological and molecular insights, whereas studies in zebrafish have allowed live imaging as well as genetic and transgenic approaches. This cross-species approach is powerful and, as we review here, has resulted in a detailed understanding of melanocyte development and differentiation, melanocyte stem cells and the role of the melanocyte lineage in diseases such as melanoma.

Indexed as

AnimalsHumansMelanocytesMelanomaMicrophthalmia-Associated Transcription FactorNeural CrestStem CellsMicrophthalmia-Associated Transcription FactorMelanomaMITFNeural crestStem cells

Identifiers

PMID25670789
PMCPMC4325379
OpenAlexW2161951166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.