ArticleThe Plant cell2015
InsP6-sensitive variants of the Gle1 mRNA export factor rescue growth and fertility defects of the ipk1 low-phytic-acid mutation in Arabidopsis.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 89 citations in OpenAlex.
- Review
- Article
- Plant PI-PLC signaling in stress and development.Plant physiology · 2025Review
- Evolution and diversification of the nuclear pore complex.Biochemical Society transactions · 2021Review
- Transcriptome analysis identifies differentially expressed genes in the progenies of a cross between two low phytic acid soybean mutants.Scientific reports · 2021Article
- Article
- Characterization and fine mapping of a new dwarf mutant in Brassica napus.BMC plant biology · 2021Article
- Network Inference of Transcriptional Regulation in Germinating Low Phytic Acid Soybean Seeds.Frontiers in plant science · 2021Article
- Analyses of Inositol Phosphates and Phosphoinositides by Strong Anion Exchange (SAX)-HPLC.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Nucleocytoplasmic Communication in Healthy and Diseased Plant Tissues.Frontiers in plant science · 2021Review
- Inositol hexakisphosphate biosynthesis underpins PAMP-triggered immunity to Pseudomonas syringae pv. tomato in Arabidopsis thaliana but is dispensable for establishment of systemic acquired resistance.Molecular plant pathology · 2020Article
- Article
- Novel allelic variant of Lpa1 gene associated with a significant reduction in seed phytic acid content in rice (Oryza sativa L.).PloS one · 2019Article
- Role for ArabidopsisFrontiers in plant science · 2018Article
- Nup42 and IPTraffic (Copenhagen, Denmark) · 2017Article
- Article
- Phospholipase C2 Affects MAMP-Triggered Immunity by Modulating ROS Production.Plant physiology · 2017Article
- Arabidopsis phosphatidylinositol-phospholipase C2 (PLC2) is required for female gametogenesis and embryo development.Planta · 2017Article
- A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies.Molecular biology of the cell · 2017Article
- Inositol Polyphosphate Binding Specificity of the Jasmonate Receptor Complex.Plant physiology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myo-inositol-1,2,3,4,5,6-hexakisphosphate (InsP(6)), also known as phytic acid, accumulates in large quantities in plant seeds, serving as a phosphorus reservoir, but is an animal antinutrient and an important source of water pollution. Here, we report that Gle1 (GLFG lethal 1) in conjunction with InsP(6) functions as an activator of the ATPase/RNA helicase LOS4 (low expression of osmotically responsive genes 4), which is involved in mRNA export in plants, supporting the Gle1-InsP(6)-Dbp5 (LOS4 homolog) paradigm proposed in yeast. Interestingly, plant Gle1 proteins have modifications in several key residues of the InsP(6) binding pocket, which reduce the basicity of the surface charge. Arabidopsis thaliana Gle1 variants containing mutations that increase the basic charge of the InsP(6) binding surface show increased sensitivity to InsP(6) concentrations for the stimulation of LOS4 ATPase activity in vitro. Expression of the Gle1 variants with enhanced InsP(6) sensitivity rescues the mRNA export defect of the ipk1 (inositol 1,3,4,5,6-pentakisphosphate 2-kinase) InsP(6)-deficient mutant and, furthermore, significantly improves vegetative growth, seed yield, and seed performance of the mutant. These results suggest that Gle1 is an important factor responsible for mediating InsP(6) functions in plant growth and reproduction and that Gle1 variants with increased InsP(6) sensitivity may be useful for engineering high-yielding low-phytate crops.
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