Evidence map›Paper›PMID 25670757›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2015

Feasibility and utility of applications of the common data model to multiple, disparate observational health databases.

Erica A Voss, Rupa Makadia, Amy Matcho, Qianli Ma, Chris Knoll, Martijn Schuemie, Frank J DeFalco, Ajit Londhe, Vivienne Zhu, Patrick B Ryan

Abstract readEvaluation Study
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erica A VossEpidemiology Analytics, Janssen Research & Development, Titusville, New Jersey, USA evoss3@its.jnj.com.
Rupa MakadiaEpidemiology Analytics, Janssen Research & Development, Titusville, New Jersey, USA.
Amy MatchoEpidemiology Analytics, Janssen Research & Development, Titusville, New Jersey, USA.
Qianli MaEpidemiology Analytics, Janssen Research & Development, Titusville, New Jersey, USA.
Chris KnollEpidemiology Analytics, Janssen Research & Development, Titusville, New Jersey, USA.
Martijn SchuemieEpidemiology Analytics, Janssen Research & Development, Titusville, New Jersey, USA.
Frank J DeFalcoEpidemiology Analytics, Janssen Research & Development, Titusville, New Jersey, USA.
Ajit LondheMedical Informatics, Janssen Research & Development, Titusville, New Jersey, USA.
Vivienne ZhuEpidemiology Analytics, Janssen Research & Development, Titusville, New Jersey, USA.
Patrick B RyanEpidemiology Analytics, Janssen Research & Development, Titusville, New Jersey, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the utility of applying the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) across multiple observational databases within an organization and to apply standardized analytics tools for conducting observational research. MATERIALS AND

methodsSix deidentified patient-level datasets were transformed to the OMOP CDM. We evaluated the extent of information loss that occurred through the standardization process. We developed a standardized analytic tool to replicate the cohort construction process from a published epidemiology protocol and applied the analysis to all 6 databases to assess time-to-execution and comparability of results.

resultsTransformation to the CDM resulted in minimal information loss across all 6 databases. Patients and observations excluded were due to identified data quality issues in the source system, 96% to 99% of condition records and 90% to 99% of drug records were successfully mapped into the CDM using the standard vocabulary. The full cohort replication and descriptive baseline summary was executed for 2 cohorts in 6 databases in less than 1 hour. DISCUSSION: The standardization process improved data quality, increased efficiency, and facilitated cross-database comparisons to support a more systematic approach to observational research. Comparisons across data sources showed consistency in the impact of inclusion criteria, using the protocol and identified differences in patient characteristics and coding practices across databases.

conclusionStandardizing data structure (through a CDM), content (through a standard vocabulary with source code mappings), and analytics can enable an institution to apply a network-based approach to observational research across multiple, disparate observational health databases.

Indexed as

Health Services ResearchVocabulary, ControlledDatabases, FactualFeasibility StudiesHumansObservational Studies as TopicSoftwarecontrolled health services researchdatabasefactual vocabularymedical informatics observational study

Identifiers

PMID25670757
PMCPMC4457111

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.