ArticleInvestigative ophthalmology & visual science2015
Measurement of retinal blood flow in normal Chinese-American subjects by Doppler Fourier-domain optical coherence tomography.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Retinal single-cell blood velocity in eyes with varied axial length using adaptive optics scanning laser ophthalmoscopy.Eye (London, England) · 2026Article
- Metabolic blood flow regulation in a hybrid model of the human retinal microcirculation.Mathematical biosciences · 2023Article
- Retinal Oxygen Delivery and Extraction in Ophthalmologically Healthy Subjects With Different Blood Pressure Status.Translational vision science & technology · 2022Article
- U-Shaped Effect of Blood Pressure on Structural OCT Metrics and Retinal Perfusion in Ophthalmologically Healthy Subjects.Investigative ophthalmology & visual science · 2021Article
- Intravital Imaging of Circulating Red Blood Cells in the Retinal Vasculature of Growing Mice.Translational vision science & technology · 2021Article
- Dorzolamide/Timolol Fixed Combination: Learning from the Past and Looking Toward the Future.Advances in therapy · 2021Review
- Repeatability and Reproducibility of Total Retinal Blood Flow Measurements Using Bi-Directional Doppler OCT.Translational vision science & technology · 2020Article
- ASSESSMENT OF RETINAL BLOOD FLOW IN DIABETIC RETINOPATHY USING DOPPLER FOURIER-DOMAIN OPTICAL COHERENCE TOMOGRAPHY.Retina (Philadelphia, Pa.) · 2017Article
- Investigation of causes of sex-related differences in ocular blood flow in healthy eyes determined by laser speckle flowgraphy.Scientific reports · 2017Article
- Aqueous humor endothelin-1 and total retinal blood flow in patients with non-proliferative diabetic retinopathy.Eye (London, England) · 2017Article
- Fluorescent Dye Labeling of Erythrocytes and Leukocytes for Studying the Flow Dynamics in Mouse Retinal Circulation.Journal of visualized experiments : JoVE · 2017Article
- Evaluating ocular blood flow.Indian journal of ophthalmology · 2017Review
- Aqueous humour concentrations of TGF-β, PLGF and FGF-1 and total retinal blood flow in patients with early non-proliferative diabetic retinopathy.Acta ophthalmologica · 2017Article
- Glaucoma Increases Retinal Surface Contour Variability as Measured by Optical Coherence Tomography.Investigative ophthalmology & visual science · 2016Article
- Measuring oxygen saturation in retinal and choroidal circulations in rats using visible light optical coherence tomography angiography.Biomedical optics express · 2015Article
- En face Doppler total retinal blood flow measurement with 70 kHz spectral optical coherence tomography.Journal of biomedical optics · 2015Article
- Ocular Blood Flow Autoregulation Mechanisms and Methods.Journal of ophthalmology · 2015Review
- Role of ocular blood flow in normal tension glaucoma.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo measure total retinal blood flow (TRBF) in normal, healthy Chinese Americans by using semi-automated analysis of Doppler Fourier-domain optical coherence tomography (FD-OCT) scans.
methodsTwo hundred sixty-six normal, healthy Chinese-American participants (266 eyes) were enrolled from The Chinese American Eye Study. All participants underwent complete ophthalmic examination, including best-corrected visual acuity, indirect ophthalmoscopy, and Doppler FD-OCT imaging, using the circumpapillary double circular scan protocol. Total retinal blood flow and other vascular parameters (e.g., venous and arterial cross-sectional area and their velocities) were calculated by using Doppler OCT of Retinal Circulation software. Associations between TRBF and other clinical parameters were assessed by using bivariate correlations and linear regression.
resultsThe mean age of study participants was 57.40 ± 5.60 (range, 50-82) years. The mean TRBF was 49.34 ± 10.08 (range, 27.17-78.08, 95% confidence interval: 25.98-69.10) μL/min. The mean venous area was 0.0548 (±0.0084) mm(2). Superior retinal hemispheric blood flow (25.50 ± 6.62 μL/min) was slightly greater than inferior retinal hemispheric blood flow (23.84 ± 7.19 μL/min, P = 0.008). The mean flow velocity was 15.16 ± 3.12 mm/s. There was a weak but significant negative correlation between TRBF and age (r = -0.15, P = 0.012). No significant correlation was found between TRBF and axial length (r = 0.11, P = 0.08). Retinal blood flow was not significantly correlated with any other clinical parameters, including body mass index, systolic blood pressure, diastolic blood pressure, and intraocular pressure.
conclusionsNormal Doppler OCT-derived total retinal blood values in a Chinese-American population showed considerable variability, some of which was explained by age. These observations should help design future studies evaluating TRBF in populations with eye disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.