ArticleScience signaling2015
Spicing up the sensation of stretch: TRPV1 controls mechanosensitive Piezo channels.
Article in Science signaling, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Vitamin D3 mediates amelioration of ulcerative colitis via the TRPV1-MAPK signaling pathway.Frontiers in immunology · 2026Article
- Localization of TRPV3/4 and PIEZO1/2 sensory receptors in murine and human larynges.Laryngoscope investigative otolaryngology · 2022Article
- TRPV1 channels as a newly identified target for vitamin D.Channels (Austin, Tex.) · 2021Review
- Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel.The Journal of physiology · 2020Article
- Functional Expression of Piezo1 in Dorsal Root Ganglion (DRG) Neurons.International journal of molecular sciences · 2020Article
- Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Review
- Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity.Frontiers in cellular neuroscience · 2018Article
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Authors and funding
1 author.
Funding
Abstract
Piezo proteins--a family of mammalian cation-selective ion channels that respond to mechanical stretch--are molecular mediators of biological processes, including vascular tone, hearing, touch, and pain. In this issue of Science Signaling, Rohacs and colleagues demonstrate that activation of the heat-sensitive transient receptor potential vanilloid 1 (TRPV1), another cation channel, inhibits Piezo channels through a calcium-induced depletion of phosphoinositides. This regulation could contribute to the cellular mechanisms by which the TRPV1 activator capsaicin mitigates mechanical hypersensitivity.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.