ArticleJournal of psychiatric research2015
S100B blood levels and childhood trauma in adolescent inpatients.
Article in Journal of psychiatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review.Brain, behavior, and immunity · 2024Pooled it
- GFAP and S100B: What You Always Wanted to Know and Never Dared to Ask.Frontiers in neurology · 2022Pooled it
- Early life adversity exposure and circulating markers of inflammation in children and adolescents: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- Increase of plasma S100B and neuron-specific enolase in children following adenotonsillectomy: a prospective clinical trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Trial
- Serum S100B and Suicidal Ideation in Major Depressive Disorder: Evidence for a Trauma-Mediated Neurobiological Pathway.International journal of molecular sciences · 2026Article
- Peripheral biological correlates of suicidality in children and adolescents: A systematic review and meta-analysis.iScience · 2025Article
- Biomarkers Unveiling the Interplay of Mind, Nervous System, and Immunity.Methods in molecular biology (Clifton, N.J.) · 2025Review
- LPS-induced whole-blood cytokine production and depressive symptoms in dementia spousal caregivers: The moderating effect of childhood trauma.Psychoneuroendocrinology · 2024Article
- Chronic early life stress alters the neuroimmune profile and functioning of the developing zebrafish gut.Brain, behavior, & immunity - health · 2023Article
- Vascular-related biomarkers in psychosis: a systematic review and meta-analysis.Frontiers in psychiatry · 2023Review
- Peripheral and neural correlates of self-harm in children and adolescents: a scoping review.BMC psychiatry · 2022Article
- Investigating Predictive Factors of Suicidal Re-attempts in Adolescents and Young Adults After a First Suicide Attempt, a Prospective Cohort Study. Study Protocol of the SURAYA Project.Frontiers in psychiatry · 2022Article
- The Blood-Brain Barrier: Much More Than a Selective Access to the Brain.Neurotoxicity research · 2021Review
- Longitudinal assessment of S100B serum levels and clinical factors in youth patients with mood disorders.Scientific reports · 2021Article
- Sterile Neuroinflammation and Strategies for Therapeutic Intervention.International journal of inflammation · 2017Review
- Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.Experimental neurology · 2016Article
- Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSerum levels of the astrocytic protein S100B have been reported to indicate disruption of the blood-brain barrier. In this study, we investigated the relationship between S100B levels and childhood trauma in a child psychiatric inpatient unit.
methodLevels of S100B were measured in a group of youth with mood disorders or psychosis with and without history of childhood trauma as well as in healthy controls. Study participants were 93 inpatient adolescents admitted with a diagnosis of psychosis (N = 67), or mood disorder (N = 26) and 22 healthy adolescents with no history of trauma or psychiatric illness. Childhood trauma was documented using the Life Events Checklist (LEC) and Adverse Child Experiences (ACE).
resultsIn a multivariate regression model, suicidality scores and trauma were the only two variables which were independently related to serum S100B levels. Patients with greater levels of childhood trauma had significantly higher S100B levels even after controlling for intensity of suicidal ideation. Patients with psychotic diagnoses and mood disorders did not significantly differ in their levels of S100B. Patients exposed to childhood trauma were significantly more likely to have elevated levels of S100B (p < .001) than patients without trauma, and patients with trauma had significantly higher S100B levels (p < .001) when compared to the control group. LEC (p = 0.046), and BPRS-C suicidality scores (p = 0.001) significantly predicted S100B levels.
conclusionsChildhood trauma can potentially affect the integrity of the blood-brain barrier as indicated by associated increased S100B levels.
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