Evidence map›Paper›PMID 25669318›Full record

ArticleEuropean journal of clinical nutrition2015

High prevalence of vitamin D deficiency in patients with xeroderma pigmetosum-A under strict sun protection.

A Kuwabara, N Tsugawa, K Tanaka, Y Uejima, J Ogawa, N Otao, N Yamada, T Masaki, C Nishigori, S Moriwaki and 1 more

Open access · bronzeAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Sunscreen photoprotection and vitamin D status.The British journal of dermatology · 2019
    Review
  5. Mechanisms and prevention of UV-induced melanoma.Photodermatology, photoimmunology & photomedicine · 2018
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

A KuwabaraDepartment of Health and Nutrition, Osaka Shoin Women's University, Higashiosaka-shi, Osaka, Japan.
N TsugawaDepartment of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan.
K TanakaDepartment of Food and Nutrition, Kyoto Women's University, Kyoto, Japan.
Y UejimaDepartment of Health and Nutrition, Osaka Shoin Women's University, Higashiosaka-shi, Osaka, Japan.
J OgawaDepartment of Health and Nutrition, Osaka Shoin Women's University, Higashiosaka-shi, Osaka, Japan.
N OtaoDepartment of Health and Nutrition, Osaka Shoin Women's University, Higashiosaka-shi, Osaka, Japan.
N YamadaDepartment of Health and Nutrition, Osaka Shoin Women's University, Higashiosaka-shi, Osaka, Japan.
T MasakiDepartment of Dermatology, Clinical Molecular Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan.ORCID 0000000317666661
C NishigoriDepartment of Dermatology, Clinical Molecular Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan.
S MoriwakiDepartment of Dermatology, Osaka Medical College, Osaka, Japan.
T OkanoDepartment of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan.
Osaka Shoin Women's University · JPKobe Pharmaceutical University · JPKobe University · JPKyoto Women's University · JPOsaka Medical and Pharmaceutical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesXeroderma pigmentosum (XP) is a rare autosomal recessive disease characterized by defective repair of ultraviolet (UV) irradiation-induced DNA damage and high risk of skin cancer. Thus, these patients require strict photoprotection. Considering the importance of UV-mediated cutaneous vitamin D production, such rigorous photoprotection would cause vitamin D deficiency. Then, we have studied the vitamin D status in patients with XP-A, a group requiring the most strict photoprotection. SUBJECTS/

methodsTwenty-one patients with XP-A (aged 6-25) were evaluated for their vitamin D intake, serum levels of 25-hydroxy-vitamin D (25OHD) and parathyroid hormone (PTH). Vitamin D intake was assessed by a 2-day food weighing method.

resultsMedian dietary intake of vitamin D was 4.1 μg/day, and the median concentrations of serum 25OHD and PTH were 7.7 and 49.9 pg/ml, respectively. In 76% of the patients, serum 25OHD level was lower than 10 ng/ml, indicating vitamin D deficiency. Vitamin D intake and serum 25OHD level were significantly lower in patients under enteral nutrition (EN) than those with oral intake (OI). Multivariate analyses revealed that EN was a significant predictor of decreased serum 25OHD level (β coefficient=-0.59, P=0.03).

conclusionsVitamin D deficiency is highly prevalent in XP-A patients, and supplementation should be considered to avoid unfavorable skeletal consequences in these patients. In addition, determination of dietary vitamin D requirement has been a difficult work issue in the decision of dietary reference intakes (DRIs) because of its cutaneous production. Data from XP patients would yield useful information for the determination of DRIs for vitamin D.

Indexed as

Life StyleNutritional StatusPatient Compliance25-Hydroxyvitamin D 2AdolescentAdultCalcifediolChildCombined Modality TherapyCross-Sectional StudiesFemaleHospitals, UniversityHumansJapanMaleOutpatient Clinics, Hospital25-Hydroxyvitamin D 2CalcifediolParathyroid HormonePTH protein, humanSunscreening Agents

Identifiers

PMID25669318
OpenAlexW1976418335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.