ArticleLangmuir : the ACS journal of surfaces and colloids2015
Hollow fiber membrane modification with functional zwitterionic macromolecules for improved thromboresistance in artificial lungs.
Article in Langmuir : the ACS journal of surfaces and colloids, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- What Are the Best Biocompatible Materials for Extracorporeal Membrane Oxygenation.Journal of functional biomaterials · 2025Review
- Antifouling Zwitterionic Polymer Coatings for Blood-Bearing Medical Devices.Langmuir : the ACS journal of surfaces and colloids · 2025Review
- Improving the hemocompatibility of a porohyperelastic layered vascular graft using luminal reversal microflows.Journal of the mechanical behavior of biomedical materials · 2024Article
- A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane.Polymers · 2023Article
- Current and Future Engineering Strategies for ECMO Therapy.Advances in experimental medicine and biology · 2023Article
- Bio-inspired hemocompatible surface modifications for biomedical applications.Progress in materials science · 2022Article
- A biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for use in blood-contacting medical devices.Journal of materials chemistry. B · 2020Article
- Toward an artificial endothelium: Development of blood-compatible surfaces for extracorporeal life support.The journal of trauma and acute care surgery · 2020Article
- Zwitterionic poly-carboxybetaine coating reduces artificial lung thrombosis in sheep and rabbits.Acta biomaterialia · 2019Article
- Active wrinkles to drive self-cleaning: A strategy for anti-thrombotic surfaces for vascular grafts.Biomaterials · 2019Article
- Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2018Article
- Novel Surfaces in Extracorporeal Membrane Oxygenation Circuits.Frontiers in medicine · 2018Review
- In vitro and in vivo evaluation of a novel integrated wearable artificial lung.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2017Article
- In Vitro Characterization of the Pittsburgh Pediatric Ambulatory Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
- Fiber Bundle Design for an Integrated Wearable Artificial Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Respiratory assist devices seek optimized performance in terms of gas transfer efficiency and thromboresistance to minimize device size and reduce complications associated with inadequate blood biocompatibility. The exchange of gas with blood occurs at the surface of the hollow fiber membranes (HFMs) used in these devices. In this study, three zwitterionic macromolecules were attached to HFM surfaces to putatively improve thromboresistance: (1) carboxyl-functionalized zwitterionic phosphorylcholine (PC) and (2) sulfobetaine (SB) macromolecules (mPC or mSB-COOH) prepared by a simple thiol-ene radical polymerization and (3) a low-molecular weight sulfobetaine (SB)-co-methacrylic acid (MA) block copolymer (SBMAb-COOH) prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. Each macromolecule type was covalently immobilized on an aminated commercial HFM (Celg-A) by a condensation reaction, and HFM surface composition changes were analyzed by X-ray photoelectron spectroscopy. Thrombotic deposition on the HFMs was investigated after contact with ovine blood in vitro. The removal of CO2 by the HFMs was also evaluated using a model respiratory assistance device. The HFMs conjugated with zwitterionic macromolecules (Celg-mPC, Celg-mSB, and Celg-SBMAb) showed expected increases in phosphorus or sulfur surface content. Celg-mPC and Celg-SBMAb experienced rates of platelet deposition significantly lower than those of unmodified (Celg-A, >95% reduction) and heparin-coated (>88% reduction) control HFMs. Smaller reductions were seen with Celg-mSB. The CO2 removal rate for Celg-SBMAb HFMs remained comparable to that of Celg-A. In contrast, the rate of removal of CO2 for heparin-coated HFMs was significantly reduced. The results demonstrate a promising approach to modifying HFMs using zwitterionic macromolecules for artificial lung devices with improved thromboresistance without degradation of gas transfer.
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