ArticleSleep2015
Behavioral sleep-wake homeostasis and EEG delta power are decoupled by chronic sleep restriction in the rat.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Effect of chronic sleep restriction on ethanol preference and cortical structural plasticity.Neurobiology of sleep and circadian rhythms · 2025Article
- Chronic dietary supplementation with nicotinamide riboside reduces sleep need in the laboratory mouse.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Homeostatic sleep regulation in the absence of the circadian sleep-regulating component: effect of short light-dark cycles on sleep-wake stages and slow waves.BMC neuroscience · 2021Article
- Differential modulation of NREM sleep regulation and EEG topography by chronic sleep restriction in mice.Scientific reports · 2020Article
- Oscillating circuitries in the sleeping brain.Nature reviews. Neuroscience · 2019Review
- Hippocampal Network Oscillations Rescue Memory Consolidation Deficits Caused by Sleep Loss.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Sleep homeostasis and the circadian clock: Do the circadian pacemaker and the sleep homeostat influence each other's functioning?Neurobiology of sleep and circadian rhythms · 2018Review
- Differential modulation of global and local neural oscillations in REM sleep by homeostatic sleep regulation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Voluntary Sleep Loss in Rats.Sleep · 2016Article
- Article
- Sleep deprivation does not affect neuronal susceptibility to mild traumatic brain injury in the rat.Nature and science of sleep · 2015Article
Corrections and comments
- Commented on by
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesChronic sleep restriction (CSR) is prevalent in society and is linked to adverse consequences that might be ameliorated by acclimation of homeostatic drive. This study was designed to test the hypothesis that the sleep-wake homeostat will acclimatize to CSR.
designA four-parameter model of proportional control was used to quantify sleep homeostasis with and without recourse to a sleep intensity function.
settingAnimal laboratory, rodent walking-wheel apparatus. SUBJECTS: Male Sprague-Dawley rats.
interventionsAcute total sleep deprivation (TSD, 1 day × 18 or 24 h, N = 12), CSR (10 days × 18 h TSD, N = 5, or 5 days × 20 h TSD, N = 6). MEASUREMENTS AND
resultsBehavioral rebounds were consistent with model predictions for proportional control of cumulative times in wake, nonrapid eye movement (NREM) and rapid eye movement (REM). Delta (D) energy homeostasis was secondary to behavioral homeostasis; a biphasic NREM D power rebound contributed to the dynamics (rapid response) but not to the magnitude of the rebound in D energy. REM behavioral homeostasis was little affected by CSR. NREM behavioral homeostasis was attenuated in proportion to cumulative NREM deficit, whereas the biphasic NREM D power rebound was only slightly suppressed, indicating decoupled regulatory mechanisms following CSR.
conclusionsWe conclude that sleep homeostasis is achieved through behavioral regulation, that the NREM behavioral homeostat is susceptible to attenuation during CSR and that the concept of sleep intensity is not essential in a model of sleep-wake regulation. STUDY
objectivesChronic sleep restriction (CSR) is prevalent in society and is linked to adverse consequences that might be ameliorated by acclimation of homeostatic drive. This study was designed to test the hypothesis that the sleep-wake homeostat will acclimatize to CSR.
designA four-parameter model of proportional control was used to quantify sleep homeostasis with and without recourse to a sleep intensity function.
settingAnimal laboratory, rodent walking-wheel apparatus. SUBJECTS: Male Sprague-Dawley rats.
interventionsAcute total sleep deprivation (TSD, 1 day × 18 or 24 h, N = 12), CSR (10 days × 18 h TSD, N = 5, or 5 days × 20 h TSD, N = 6). MEASUREMENTS AND
resultsBehavioral rebounds were consistent with model predictions for proportional control of cumulative times in wake, nonrapid eye movement (NREM) and rapid eye movement (REM). Delta (D) energy homeostasis was secondary to behavioral homeostasis; a biphasic NREM D power rebound contributed to the dynamics (rapid response) but not to the magnitude of the rebound in D energy. REM behavioral homeostasis was little affected by CSR. NREM behavioral homeostasis was attenuated in proportion to cumulative NREM deficit, whereas the biphasic NREM D power rebound was only slightly suppressed, indicating decoupled regulatory mechanisms following CSR.
conclusionsWe conclude that sleep homeostasis is achieved through behavioral regulation, that the NREM behavioral homeostat is susceptible to attenuation during CSR and that the concept of sleep intensity is not essential in a model of sleep-wake regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.