Trial reportSleep2015
The Effect of Adenotonsillectomy for Childhood Sleep Apnea on Cardiometabolic Measures.
Trial report in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00560859 (A Randomized Controlled Study of Adenotonsillectomy for Children With Obstructive Sleep Apnea Syndrome), which is not on this map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Study of Adenotonsillectomy for Children With Obstructive Sleep Apnea Syndrome
Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Lingual Tonsillectomy for Treatment of Pediatric Obstructive Sleep Apnea: A Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2017Pooled it
- Postoperative Bleeding and Associated Utilization following Tonsillectomy in Children.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2017Pooled it
- Pooled it
- Pooled it
- Tonsillectomy or adenotonsillectomy versus non-surgical management for obstructive sleep-disordered breathing in children.The Cochrane database of systematic reviews · 2015Pooled it
- Adenotonsillectomy and Blood Pressure in Children With Mild Obstructive Sleep-Disordered Breathing: An Exploratory Analysis of the PATS Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2025Trial
- Objective sleep quality and metabolic risk in healthy weight children results from the randomized Childhood Adenotonsillectomy Trial (CHAT).Sleep & breathing = Schlaf & Atmung · 2019Trial
- Effect of adenotonsillectomy for childhood obstructive sleep apnea on nocturnal heart rate patterns.Sleep · 2018Trial
- Paediatric obstructive sleep apnoea and early cardiovascular risk phenotypes: an evidence review.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- The Natural History of Obstructive Sleep Apnea: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Indications for Adenoidectomy and Tonsillectomy for Obstructive Sleep Apnea in Children and Adolescents.Children (Basel, Switzerland) · 2025Review
- Impact of Adenotonsillectomy on Weight Gain in Children: A Systematic Review.Children (Basel, Switzerland) · 2025Review
- Childhood Obstructive Sleep Apnea and Systemic Blood Pressure and Kidney Function: A Systematic Review and Meta-Analysis.International journal of hypertension · 2025Review
- Adenotonsillectomy Versus Watchful Waiting for Children with Obstructive Sleep Apnea Syndrome: A Systematic Review with Meta-Analysis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Interpretation of sleep studies and perioperative considerations in children with sleep-disordered breathing.BJA education · 2023Review
- Sleep quality, sleep apnea, and metabolic health in children treated with adenotonsillectomy.Sleep & breathing = Schlaf & Atmung · 2023Article
- Heart rate variability as a potential biomarker of pediatric obstructive sleep apnea resolution.Sleep · 2022Article
- Association of Pediatric Obstructive Sleep Apnea With Elevated Blood Pressure and Orthostatic Hypertension in Adolescence.JAMA cardiology · 2021Article
- Parental Perception of Weight Status for Adenotonsillectomy Patients.The Laryngoscope · 2021Article
- Analyses of Weight/Blood Pressure Changes before and after Tonsillectomy in Adults: A Longitudinal Follow-Up Study.International journal of environmental research and public health · 2021Article
Corrections and comments
- Commented on by
Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
STUDY
objectivesObstructive sleep apnea syndrome (OSAS) has been associated with cardiometabolic disease in adults. In children, this association is unclear. We evaluated the effect of early adenotonsillectomy (eAT) for treatment of OSAS on blood pressure, heart rate, lipids, glucose, insulin, and C-reactive protein. We also analyzed whether these parameters at baseline and changes at follow-up correlated with polysomnographic indices.
designData collected at baseline and 7-mo follow-up were analyzed from a randomized controlled trial, the Childhood Adenotonsillectomy Trial (CHAT).
settingClinical referral setting from multiple centers.
participantsThere were 464 children, ages 5 to 9.9 y with OSAS without severe hypoxemia.
interventionsRandomization to eAT or Watchful Waiting with Supportive Care (WWSC). MEASUREMENTS AND
resultsThere was no significant change of cardiometabolic parameters over the 7-mo interval in the eAT group compared to WWSC group. However, overnight heart rate was incrementally higher in association with baseline OSAS severity (average heart rate increase of 3 beats per minute [bpm] for apnea-hypopnea index [AHI] of 2 versus 10; [standard error = 0.60]). Each 5-unit improvement in AHI and 5 mmHg improvement in peak end-tidal CO2 were estimated to reduce heart rate by 1 and 1.5 bpm, respectively. An increase in N3 sleep also was associated with small reductions in systolic blood pressure percentile.
conclusionsThere is little variation in standard cardiometabolic parameters in children with obstructive sleep apnea syndrome (OSAS) but without severe hypoxemia at baseline or after intervention. Of all measures, overnight heart rate emerged as the most sensitive parameter of pediatric OSAS severity. CLINICAL
trial registrationClinicaltrials.gov (#NCT00560859).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.