Evidence map›Paper›PMID 25669151›Full record

ArticleMucosal immunology2015

Phenotype and function of nasal dendritic cells.

H Lee, D Ruane, K Law, Y Ho, A Garg, A Rahman, D Esterházy, C Cheong, E Goljo, A G Sikora and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

H Lee1] Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA [2] Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
D Ruane1] Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA [2] Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
K Law1] Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA [2] Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Y HoDepartment of Otorhinolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
A GargDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
A Rahman1] Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA [2] Flow Cytometry Shared Resource Facility, Icahn School of Medicine, New York, New York, USA.
D EsterházyLaboratory of Mucosal Immunology, Rockefeller University, New York, New York, USA.
C CheongLaboratory of Cellular Immunology and Physiology, Institut de Recherches Cliniques de Montréal and Department of Microbiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.
E GoljoDepartment of Otorhinolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
A G SikoraBobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.
D MucidaLaboratory of Mucosal Immunology, Rockefeller University, New York, New York, USA.
B K Chen1] Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA [2] Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
S GovindrajDepartment of Otorhinolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
G BretonLaboratory of Molecular Immunology, Rockefeller University, New York, New York, USA.
S Mehandru1] Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA [2] Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Icahn School of Medicine at Mount Sinai · USRockefeller University · USBaylor College of Medicine · USInstitute for Clinical Social Work · USMontreal Clinical Research Institute · CA

Funding

TRANSFORMING TRANSLATIONAL SCIENCE AND EDUCATION TO BENEFIT HUMAN HEALTHUL1RR024143 · NCRR · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2006 to 2011
$49.1M
Transforming Translational Science and Education to Benefit Human HealthUL1TR000043 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2012 to 2015
$26.8M
Imaging Virological Synapses During Parenteral HIV TransmissionDP1DA028866 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHEN, BENJAMIN K · 2009 to 2013
$4.1M
Antigen presentation in the intestine: initiating events in oral toleranceR56AI119062 · NIAID · ROCKEFELLER UNIVERSITY · PI MUCIDA, DANIEL S · 2015 to 2015
$424k
Role of cell-to-cell HIV-1 spread in vivo during intravenous transmissionF31DA036425 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LAW, KENNETH MARVIN · 2013 to 2015
$110k
NCATS NIH HHS 8 UL 1 TR000043NCRR NIH HHS 5UL1RR024143-05NCRR NIH HHS UL1 RR024143NIAID NIH HHS R56 AI119062NIDA NIH HHS DP1DA028866NIDA NIH HHS F31DA036425
6 · The paper itself

Abstract

Intranasal (i.n.) vaccination generates immunity across local, regional, and distant sites. However, nasal dendritic cells (DCs), pivotal for the induction of i.n. vaccine-induced immune responses, have not been studied in detail. Here, by using a variety of parameters, we define nasal DCs in mice and humans. Distinct subsets of "classical" DCs, dependent on the transcription factor zbtb46 were identified in the murine nose. The murine nasal DCs were Fms-related tyrosine 3 kinase ligand responsive and displayed unique phenotypic and functional characteristics, including the ability to present antigen, induce an allogeneic T-cell response, and migrate in response to lipopolysaccharide or live bacterial pathogens. Importantly, in a cohort of human volunteers, BDCA-1(+) DCs were observed to be the dominant nasal DC population at steady state. During chronic inflammation, the frequency of both BDCA-1(+) and BDCA-3(hi) DCs was reduced in the nasal tissue, associating the loss of these immune sentinels with chronic nasal inflammation. The present study is the first detailed description of the phenotypic, ontogenetic, and functional properties of nasal DCs, and will inform the design of preventative immunization strategies as well as therapeutic modalities against chronic rhinosinusitis.

Indexed as

AnimalsAntigens, CD1Antigens, SurfaceDendritic CellsDNA-Binding ProteinsGlycoproteinsHumansMiceMice, Inbred BALB CNasal MucosaRhinitisSinusitisThrombomodulinTranscription FactorsAntigens, CD1Antigens, SurfaceCD1C protein, humanDNA-Binding ProteinsGlycoproteinsTHBD protein, humanThrombomodulinTranscription FactorsZbtb46 protein, mouseZBTB7A protein, human

Identifiers

PMID25669151
PMCPMC4532662
OpenAlexW1991936408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.