ArticleAmerican journal of respiratory and critical care medicine2015
Improving selection criteria for lung cancer screening. The potential role of emphysema.
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02705144 (Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis Compared to Non-diseased Areas), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis Compared to Non-diseased Areas
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Population-Based Screening Using Low-Dose Chest Computed Tomography: A Systematic Review of Health Economic Evaluations.PharmacoEconomics · 2023Pooled it
- The prevalence of comorbidity in the lung cancer screening population: A systematic review and meta-analysis.Journal of medical screening · 2023Pooled it
- Trial
- Plasma biomarkers predicting development of lung cancer 5 years before diagnosis.Journal of hematology & oncology · 2026Article
- Integration of circulating tumor DNA data enhances lung cancer prediction in patients with COPD.Scientific reports · 2026Article
- Personalised screening intensity based on existing lung cancer risk and spirometry.ERJ open research · 2026Article
- Emphysema and lung cancer risk.Translational lung cancer research · 2024Article
- Blood-based DNA methylation markers for lung cancer prediction.BMJ oncology · 2024Article
- The Early Diagnosis of Lung Cancer: Critical Gaps in the Discovery of Biomarkers.Journal of clinical medicine · 2023Review
- ERS/ESTS/ESTRO/ESR/ESTI/EFOMP statement on management of incidental findings from low dose CT screening for lung cancer.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023Article
- International expert consensus on diagnosis and treatment of lung cancer complicated by chronic obstructive pulmonary disease.Translational lung cancer research · 2023Review
- Chronic Obstructive Pulmonary Disease and Lung Cancer: A Review for Clinicians.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2022Article
- Lung cancer in recipients after lung transplant: single-centre experience and literature review.BMJ open respiratory research · 2022Review
- The Journey for Lung Cancer Screening where we Stand Today.The open respiratory medicine journal · 2022Review
- Comorbidity Profiles and Lung Cancer Screening among Older Adults: U.S. Behavioral Risk Factor Surveillance System 2017-2019.Annals of the American Thoracic Society · 2021Article
- Performance of various risk prediction models in a large lung cancer screening cohort in Gdańsk, Poland-a comparative study.Translational lung cancer research · 2021Article
- Molecular biomarkers in early stage lung cancer.Translational lung cancer research · 2021Review
- The Regimen of Computed Tomography Screening for Lung Cancer: Lessons Learned Over 25 Years From the International Early Lung Cancer Action Program.Journal of thoracic imaging · 2021Article
- Lung emphysema and lung cancer: what do we know about it?Annals of translational medicine · 2020Review
- Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe.Cancers · 2020Review
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
rationaleLung cancer (LC) screening using low-dose chest computed tomography is now recommended in several guidelines using the National Lung Screening Trial (NLST) entry criteria (age, 55-74; ≥30 pack-years; tobacco cessation within the previous 15 yr for former smokers). Concerns exist about their lack of sensitivity.
objectivesTo evaluate the performance of NLST criteria in two different LC screening studies from Europe and the United States, and to explore the effect of using emphysema as a complementary criterion.
methodsParticipants from the Pamplona International Early Lung Action Detection Program (P-IELCAP; n = 3,061) and the Pittsburgh Lung Screening Study (PLuSS; n = 3,638) were considered. LC cumulative frequencies, incidence densities, and annual detection rates were calculated in three hypothetical cohorts, including subjects who met NLST criteria alone, those with computed tomography-detected emphysema, and those who met NLST criteria and/or had emphysema. MEASUREMENTS AND MAIN
resultsThirty-six percent and 59% of P-IELCAP and PLuSS participants, respectively, met NLST criteria. Among these, higher LC incidence densities and detection rates were observed. However, applying NLST criteria to our original cohorts would miss as many as 39% of all LC. Annual screening of subjects meeting either NLST criteria or having emphysema detected most cancers (88% and 95% of incident LC of P-IELCAP and PLuSS, respectively) despite reducing the number of screened participants by as much as 52%.
conclusionsLC screening based solely on NLST criteria could miss a significant number of LC cases. Combining NLST criteria and emphysema to select screening candidates results in higher LC detection rates and a lower number of cancers missed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.