ArticleVirulence2015
Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis.
Article in Virulence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The Historical Burden of Sporotrichosis in Brazil: a Systematic Review of Cases Reported from 1907 to 2020.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Pooled it
- Susceptibility Profiles Among Sporothrix brasiliensis Genotypes in the Ongoing Zoonotic Sporotrichosis Epidemic in Brazil, Argentina and Paraguay.Mycopathologia · 2026Article
- Osteoarticular Sporotrichosis in a Brazilian Endemic Setting: Associated Factors and Outcomes.Mycoses · 2026Article
- Diabetes impairs antifungal immunity and drives fatal disseminated sporotrichosis in mice.Frontiers in immunology · 2026Article
- Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review.Medical mycology case reports · 2025Article
- Quality of Life, Disability, and Fungal Neglected Tropical Diseases.Current fungal infection reports · 2025Article
- Novel Insights into Sporotrichosis and Diabetes.Journal of fungi (Basel, Switzerland) · 2024Review
- Review
- A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis.Journal of fungi (Basel, Switzerland) · 2024Article
- Case Report: Osteomyelitis Due to Sporothrix brasiliensis in Two Immunocompetent Patients Requiring Surgical Amputation.The American journal of tropical medicine and hygiene · 2023Article
- Article
- Cutaneous disseminated sporotrichosis associated with diabetes: A case report and literature review.PLoS neglected tropical diseases · 2023Review
- Metabolic Plasticity and Virulence-Associated Factors ofJournal of fungi (Basel, Switzerland) · 2023Article
- Osteoarticular Mycoses.Clinical microbiology reviews · 2022Review
- Epidemiology of Clinical Sporotrichosis in the Americas in the Last Ten Years.Journal of fungi (Basel, Switzerland) · 2022Review
- Molecular and phenotypic reidentification ofCurrent research in microbial sciences · 2022Article
- Bone sporotrichosis: 41 cases from a reference hospital in Rio de Janeiro, Brazil.PLoS neglected tropical diseases · 2021Article
- Evolution of virulence-related phenotypes of Sporothrix brasiliensis isolates from patients with chronic sporotrichosis and acquired immunodeficiency syndrome.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Complement-Mediated Differential Immune Response of Human Macrophages toFrontiers in immunology · 2021Article
- Molecular Identification and Antifungal Susceptibility of Clinical Isolates of Sporothrix schenckii Complex in Medellin, Colombia.Mycopathologia · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The metropolitan region of Rio de Janeiro is hyperendemic for cat-associated sporotrichosis. This study aimed to assess the virulence of serial Sporothrix isolates from a 61-year-old male patient with chronic, destructive disseminated sporotrichosis. Five Sporothrix isolates were cultured from skin exudates and bone samples over a 5-year period, and all were molecularly identified as Sporothrix brasiliensis. The final isolate was significantly more virulent in Galleria mellonella larvae compared to earlier isolates. We conclude that S. brasiliensis has the capacity to increase in virulence in vivo. This finding is significant to clinicians caring for individuals with S. brasiliensis disease and it suggests that further studies are needed to identify the mechanisms underlying pathogenicity enhancement during chronic disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.