ArticlePloS one2015
Comparison of SPECT/CT and MRI in diagnosing symptomatic lesions in ankle and foot pain patients: diagnostic performance and relation to lesion type.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Trial
- Imaging modalities for non-acute pathologies of the foot and ankle.Journal of clinical orthopaedics and trauma · 2024Article
- [Radiological-nuclear medicine hybrid diagnostics with SPECT/CT for chronic foot and ankle diseases : A new and important diagnostic tool].Orthopadie (Heidelberg, Germany) · 2023Review
- CT-Based Calculation Model Assists Precise Treatment for Anterior and Posterior Ankle Bony Impingement.Orthopaedic surgery · 2023Article
- Clinical impact of 99mTc-HDP SPECT/CT imaging as standard workup for foot and ankle osteoarthritis.BJR open · 2023Article
- KSNM 60 in General Nuclear Medicine: the Old Dream Comes True.Nuclear medicine and molecular imaging · 2022Review
- Bone scan with SPECT/CT in children with complex foot and ankle pain: Initial experience of a paediatric tertiary referral centre.Journal of children's orthopaedics · 2020Article
- Bone SPECT/CT of the Foot and Ankle: Potential Clinical Application for Chronic Foot Pain.Nuclear medicine and molecular imaging · 2020Review
- Os calcaneus secundarius, a relevant differential diagnosis to fracture or pseudarthrosis of processus anterior of the calcaneus: a CT morphologic description.Surgical and radiologic anatomy : SRA · 2019Article
- Beyond the bones and joints: a review of ligamentous injuries of the foot and ankle onThe British journal of radiology · 2019Review
- Two decades of SPECT/CT - the coming of age of a technology: An updated review of literature evidence.European journal of nuclear medicine and molecular imaging · 2019Review
- Article
- The role of hybrid bone SPECT/CT imaging in the work-up of the limping patient: a symptom-based and joint-oriented review.European journal of hybrid imaging · 2018Review
- Bone scintigraphy in patients with pain.The Korean journal of pain · 2017Review
- Correlation of Uptake Patterns on Single-Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) and Treatment Response in Patients with Knee Pain.Nuclear medicine and molecular imaging · 2016Article
- Contemporary approaches for imaging skeletal metastasis.Bone research · 2015Review
- Technetium-99m Methylene Diphosphonate Single-photon Emission Computed Tomography/Computed Tomography of the Foot and Ankle.World journal of nuclear medicineReview
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to compare the diagnostic performance of SPECT/CT and MRI in patients with ankle and foot pain, with regard to the lesion types. MATERIALS AND
methodsFifty consecutive patients with ankle and foot pain, who underwent 99mTc-MDP SPECT/CT and MRI, were retrospectively enrolled in this study. Symptomatic lesions were determined based on clinical examination and response to treatment. On MRI and SPECT/CT, detected lesions were classified as bone, ligament/tendon, and joint lesions. Uptake on SPECT/CT was assessed using a 4-grade system. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of SPECT/CT and MRI were evaluated in all detected lesions and each lesion type. Diagnostic value of uptake grade was analyzed using receiver-operating characteristics (ROC) curve analysis, and diagnostic performance was compared using Chi-square or McNemar tests.
resultsIn overall lesions, the sensitivity, PPV and NPV of SPECT/CT for symptomatic lesions were 93%, 56%, 91%, and they were 98%, 48%, 95% for MRI. There was no significant difference between SPECT/CT and MRI. However, the specificity of SPECT/CT was significantly higher than that of MRI (48% versus 24%, P = 0.016). Uptake grade on SPECT/CT was significantly higher in symptomatic lesions (P < 0.001), and its area under curve on ROC analysis was 0.787. In the analysis of each lesion type, the specificity of SPECT/CT was poor in joint lesions compared with other lesion types and MRI (P < 0.001, respectively). MRI exhibited lower specificity than SPECT/CT in bone lesions (P = 0.004) and ligament/tendon lesions (P < 0.001).
conclusionsSPECT/CT has MRI-comparable diagnostic performance for symptomatic lesions in ankle and foot pain patients. SPECT/CT and MRI exhibit different diagnostic specificity in different lesion types. SPECT/CT may be used as a complementary imaging method to MRI for enhancing diagnostic specificity.
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