Evidence map›Paper›PMID 25668150›Full record

ArticleMicrobial drug resistance (Larchmont, N.Y.)2015

Recurrent furunculosis caused by a community-acquired Staphylococcus aureus strain belonging to the USA300 clone.

Shirish Balachandra, Maria Pardos de la Gandara, Scott Salvato, Tracie Urban, Claude Parola, Chamanara Khalida, Rhonda G Kost, Teresa H Evering, Mina Pastagia, Brianna M D'Orazio and 3 more

Open access · greenAbstract read
In one paragraph

Article in Microbial drug resistance (Larchmont, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Molecular Epidemiologic and Geo-Spatial Characterization ofAntibiotics (Basel, Switzerland) · 2023
    Article
  2. Stakeholder Engagement In a Comparative Effectiveness/Implementation Study to PreventProgress in community health partnerships : research, education, and action · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. From the Bench to the Barbershop: Community Engagement to Raise Awareness About Community-Acquired Methicillin-ResistantProgress in community health partnerships : research, education, and action · 2016
    Article
  7. Article
  8. Observational
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Shirish Balachandra1 Urban Health Plan , Bronx, New York.
Maria Pardos de la Gandara
Scott Salvato
Tracie Urban
Claude Parola
Chamanara Khalida
Rhonda G Kost
Teresa H Evering
Mina Pastagia
Brianna M D'Orazio
Alexander Tomasz
Herminia de Lencastre
Jonathan N Tobin
Rockefeller University · USClinical Directors Network · US

Funding

Transforming Translational Science and Education to Benefit Human HealthUL1TR000043 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2012 to 2015
$26.8M
N2: Building a Network of Safety Net PBRNsP30HS021667 · AHRQ · CLINICAL DIRECTORS NETWORK, INC. · PI TOBIN, JONATHAN N · 2012 to 2016
$595k
AHRQ HHS 1 P30-HS-021667AHRQ HHS P30 HS021667NCATS NIH HHS UL1 TR000043NCATS NIH HHS UL1 TR000043-07S1
6 · The paper itself

Abstract

backgroundA 24-year-old female with recurrent skin and soft tissue infections (SSTI) was enrolled as part of a multicenter observational cohort study conducted by a practice-based research network (PBRN) on community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA).

methodsStrains were characterized by pulsed-field gel electrophoresis (PFGE), spa typing, and multilocus sequence typing. MRSA strains were analyzed for SCCmec type and the presence of the Panton-Valentine leukocidin (PVL) and arginine catabolic mobile element (ACME) using PCR.

resultsIn the first episode, S. aureus was recovered from the wound and inguinal folds; in the second, S. aureus was recovered from a lower abdomen furuncle, inguinal folds, and patellar fold. Molecular typing identified CA-MRSA clone USA300 in all samples as spa-type t008, ST8, SCCmecIVa, and a typical PFGE pattern. The strain carried virulence genes pvl and ACME type I. Five SSTI episodes were documented despite successful resolution by antibiotic treatment, with and without incision and drainage.

conclusionsThe source of the USA300 strain remains unknown. The isolate may represent a persistent strain capable of surviving extensive antibiotic pressure or a persistent environmental reservoir may be the source, possibly in the patient's household, from which bacteria were repeatedly introduced into the skin flora with subsequent infections.

Indexed as

AdultAnti-Bacterial AgentsBacterial ToxinsCohort StudiesExotoxinsFemaleFurunculosisHumansInterspersed Repetitive SequencesLeukocidinsMethicillin-Resistant Staphylococcus aureusSoft Tissue InfectionsStaphylococcal InfectionsVirulenceVirulence FactorsYoung AdultAnti-Bacterial AgentsBacterial ToxinsExotoxinsLeukocidinsPanton-Valentine leukocidinVirulence Factors

Identifiers

PMID25668150
PMCPMC4519049
OpenAlexW1507324234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.