Trial reportBritish journal of cancer2015
A multi-centre randomised trial comparing ultrasound vs mammography for screening breast cancer in high-risk Chinese women.
Trial report in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 5 syntheses or guidelines pooled it, 191 citations in OpenAlex.
- Breast cancer screening and early diagnosis in China: a systematic review and meta-analysis on 10.72 million women.BMC women's health · 2024Pooled it
- Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk.The Cochrane database of systematic reviews · 2023Pooled it
- A systematic review and meta-analysis comparing the diagnostic capability of automated breast ultrasound and contrast-enhanced ultrasound in breast cancer.Frontiers in oncology · 2023Pooled it
- Performance of ultrasonography screening for breast cancer: a systematic review and meta-analysis.BMC cancer · 2020Pooled it
- Ultrasound for Breast Cancer Detection Globally: A Systematic Review and Meta-Analysis.Journal of global oncology · 2019Pooled it
- Comparison of ultrasound and mammography for early diagnosis of breast cancer among Chinese women with suspected breast lesions: A prospective trial.Thoracic cancer · 2022Trial
- The Clinical Application of Combined Ultrasound, Mammography, and Tumor Markers in Screening Breast Cancer among High-Risk Women.Computational and mathematical methods in medicine · 2022Trial
- Cancer burden and control in China: landscape, trends and challenges.Nature reviews. Clinical oncology · 2026Review
- Five-Year Breast Cancer Risk Prediction From Screening Breast Ultrasound Using Deep Learning.medRxiv : the preprint server for health sciences · 2026Article
- Plasma proteome-metabolome signatures enable non-invasive early detection and lymph node risk stratification in breast cancer.Molecular cancer · 2026Article
- An interpretable ultrasound-based deep learning system for early breast cancer in a Chinese population.Insights into imaging · 2026Article
- Breast Cancer Screening Programs in China: Implementation, Challenges, and Future Perspectives.Korean journal of radiology · 2026Review
- Radiological Control After Reduction Mammoplasty: Do Ultrasonographic Postoperative Changes Return to Normal in the Late Period?The Eurasian journal of medicine · 2026Article
- A foundation generative model for breast ultrasound image analysis.Nature biomedical engineering · 2026Article
- Cost-effectiveness of two major population-based breast cancer screening programmes in China: a model-based economic evaluation.BMJ public health · 2026Article
- Panoramic photoacoustic computed tomography with learning-based classification enhances breast lesion characterization.Nature biomedical engineering · 2026Article
- A cost-effective breast cancer screening strategy for Urban China: Findings from a Shenzhen-based modeling study.PloS one · 2026Article
- Epidemiology, early detection, and management of breast cancer in China: A comprehensive review.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Cancer statistics in China: Epidemiology, risk factors, and prevention.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Bridging the skill gap in breast ultrasound: a PDCA management for standardized reporting and accurate BI-RADS categorization in postgraduate medical education.BMC medical education · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChinese women tend to have small and dense breasts and ultrasound is a common method for breast cancer screening in China. However, its efficacy and cost comparing with mammography has not been evaluated in randomised trials.
methodsAt 14 breast centres across China during 2008-2010, 13 339 high-risk women aged 30-65 years were randomised to be screened by mammography alone, ultrasound alone, or by both methods at enrollment and 1-year follow-up.
resultsA total of 12 519 and 8692 women underwent the initial and second screenings, respectively. Among the 30 cancers (of which 15 were stage 0/I) detected, 5 (0.72/1000) were in the mammography group, 11 (1.51/1000) in the ultrasound group, and 14 (2.02/1000) in the combined group (P=0.12). In the combined group, ultrasound detected all the 14 cancers, whereas mammography detected 8, making ultrasound more sensitive (100 vs 57.1%, P=0.04) with a better diagnostic accuracy (0.999 vs 0.766, P=0.01). There was no difference between mammography and ultrasound in specificity (100 vs 99.9%, P=0.51) and positive predictive value (72.7 vs 70.0%; P=0.87). To detect one cancer, the costs of ultrasound, mammography, and combined modality were $7876, $45 253, and $21 599, respectively.
conclusionsUltrasound is superior to mammography for breast cancer screening in high-risk Chinese women.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.