Evidence map›Paper›PMID 25668011›Full record

ArticleBritish journal of cancer2015

Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA).

J L Petrick, S E Steck, P T Bradshaw, K F Trivers, P E Abrahamson, L S Engel, K He, W-H Chow, S T Mayne, H A Risch and 2 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 9 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 9 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

J L PetrickDepartment of Epidemiology, CB 7435, University of North Carolina, Chapel Hill, NC 27599-7435, USA.
S E SteckDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
P T BradshawDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
K F TriversDivision of Cancer Prevention and Control, Centers for Disease Control, Atlanta, GA, USA.
P E AbrahamsonSalmon Bay Consulting, Inc., Seattle, WA, USA.
L S EngelDepartment of Epidemiology, CB 7435, University of North Carolina, Chapel Hill, NC 27599-7435, USA.
K HeDepartment of Epidemiology and Biostatistics, Indiana University, Bloomington, IN, USA.
W-H ChowDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
S T MayneDepartment of Chronic Disease Epidemiology, Yale School of Public Health and Yale Cancer Center, New Haven, CT, USA.
H A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health and Yale Cancer Center, New Haven, CT, USA.
T L VaughanDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
M D GammonDepartment of Epidemiology, CB 7435, University of North Carolina, Chapel Hill, NC 27599-7435, USA.
University of North Carolina at Chapel Hill · USYale University · USCenters for Disease Control and Prevention · USFred Hutch Cancer Center · USIndiana University Bloomington · USThe University of Texas MD Anderson Cancer Center · USUniversity of South Carolina · USWild Salmon Center · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
TRAINING GRANT IN CANCER EPIDEMIOLOGYT32CA009330 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLSHAN, ANDREW · 1985 to 2010
$2.5M
ESTABLISHED INVESTIGATOR AWARD IN CANCER PREVENTION AND CONTROLK05CA124911 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VAUGHAN, THOMAS L · 2007 to 2016
$1.6M
Flavonoids, esophageal/gastric cardia adenocarcinoma and Barretts Esophagus RiskR03CA159409 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GAMMON, MARILIE D. · 2012 to 2013
$140k
EPIDEMIOLOGIC STUDY OF ESOPHAGEAL/GASTRIC ADENOCARCINOMAU01CA057923 · NCI · YALE UNIVERSITY · PI RISCH, HARVEY A · 1992 to 1995
–
EPIDEMIOLOGIC STUDY OF ADENOCARCINOMAS OF THE ESOPHAGUSU01CA057949 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VAUGHAN, THOMAS L · 1992 to 1995
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ADENOCARCINOMAS OF THE ESOPHAGUS AND GASTRIC CARDIAU01CA057983 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GAMMON, MARILIE D · 1992 to 1995
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NCI NIH HHS K05 CA124911NCI NIH HHS R03 CA159409NCI NIH HHS R03-CA159409NCI NIH HHS T32 CA009330NCI NIH HHS T32-CA009330NCI NIH HHS U01 CA057923NCI NIH HHS U01-CA057923NCI NIH HHS U01 CA057949NCI NIH HHS U01-CA057949NCI NIH HHS U01 CA057983NCI NIH HHS U01-CA057983NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30-ES10126NIEHS NIH HHS T32 ES007018NIEHS NIH HHS T32-ES007018
6 · The paper itself

Abstract

backgroundFlavonoids, polyphenolic compounds concentrated in fruits and vegetables, have experimentally demonstrated chemopreventive effects against oesophageal and gastric cancer. Few epidemiologic studies have examined flavonoid intake and incidence of these cancers, and none have considered survival.

methodsIn this USA multicentre population-based study, case participants (diagnosed during 1993-1995 with oesophageal adenocarcinoma (OEA, n=274), gastric cardia adenocarcinoma (GCA, n=248), oesophageal squamous cell carcinoma (OES, n=191), and other gastric adenocarcinoma (OGA, n=341)) and frequency-matched controls (n=662) were interviewed. Food frequency questionnaire responses were linked with USDA Flavonoid Databases and available literature for six flavonoid classes and lignans. Case participants were followed until 2000 for vital status. Multivariable-adjusted odds ratios (ORs) and hazard ratios (HRs) (95% confidence intervals (CIs)) were estimated, comparing highest with lowest intake quartiles, using polytomous logistic and proportional hazards regressions, respectively.

resultsLittle or no consistent association was found for total flavonoid intake (main population sources: black tea, orange/grapefruit juice, and wine) and incidence or survival for any tumour type. Intake of anthocyanidins, common in wine and fruit juice, was associated with a 57% reduction in the risk of incident OEA (OR=0.43, 95% CI=0.29-0.66) and OES (OR=0.43, 95% CI=0.26-0.70). The ORs for isoflavones, for which coffee was the main source, were increased for all tumours, except OES. Anthocyanidins were associated with decreased risk of mortality for GCA (HR=0.63, 95% CI=0.42-0.95) and modestly for OEA (HR=0.87, 95% CI=0.60-1.26), but CIs were wide.

conclusionsOur findings, if confirmed, suggest that increased dietary anthocyanidin intake may reduce incidence and improve survival for these cancers.

Indexed as

Case-Control StudiesDietEsophageal NeoplasmsFemaleFlavonoidsFruitHumansIncidenceMaleRisk FactorsStomach NeoplasmsSurvival AnalysisUnited StatesVegetablesFlavonoids

Identifiers

PMID25668011
PMCPMC4385952
OpenAlexW2088933260

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.