Evidence map›Paper›PMID 25667922›Full record

ArticleBioMed research international2015

Analysis of single nucleotide polymorphisms within ADAM12 and risk of knee osteoarthritis in a Chinese Han population.

Lin Wang, Lin Guo, Fengde Tian, Ruihu Hao, Tiejun Yang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 5 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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  9. Association ofOncotarget · 2017
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  11. The association ofTherapeutics and clinical risk management · 2017
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  13. A Sparse Regression Method for Group-Wise Feature Selection with False Discovery Rate Control.IEEE/ACM transactions on computational biology and bioinformatics
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lin WangDepartment of Orthopaedics, The Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Road, Da Lian, China.
Lin GuoDepartment of Orthopaedics, The Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Road, Da Lian, China.
Fengde TianDepartment of Orthopaedics, The Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Road, Da Lian, China.
Ruihu HaoDepartment of Orthopaedics, The Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Road, Da Lian, China.
Tiejun YangDepartment of Orthopaedics, The Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Road, Da Lian, China.
Affiliated Zhongshan Hospital of Dalian University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOsteoarthritis (OA) is a complex arthritic condition in which the genetic factor plays a major role. One of the candidate genes of is the ADAM12 gene, but no consistency has been reached till now. This study aims to investigate the potential role of four single nucleotide polymorphisms (SNPs) of the ADAM12 gene in susceptibility to knee OA and its progression in Chinese Han population.

methodsThe rs1278279, rs3740199, rs1044122, and rs1871054 polymorphisms were genotyped and compared in a population based cohort consisting of 164 OA subjects and 200 age- and gender-matched controls.

resultsThe SNP rs1871054 was found with increased risk of OA susceptibility in comparing the genotype frequencies between the case and control groups no matter for which model of comparison (allele level, dominant model, recessive model, and extreme genotype model). Additionally, the SNP rs1871054 was found associated with increased OA severity according to the K/L grade.

conclusionIn summary, we have identified that the rs1871054 variant within the ADAM12 gene is a risk factor for increased osteoarthritis susceptibility and severity.

Indexed as

ADAM12 ProteinADAM ProteinsAgedAsian PeopleCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansMaleMembrane ProteinsMiddle AgedOsteoarthritis, KneePolymorphism, Single NucleotideADAM12 ProteinADAM12 protein, humanADAM ProteinsMembrane Proteins

Identifiers

PMID25667922
PMCPMC4312576
OpenAlexW2084139477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.