Evidence map›Paper›PMID 25667856›Full record

ArticleEpilepsy & behavior case reports2014

Myoclonus in renal failure: Two cases of gabapentin toxicity.

Kenneth R Kaufman, Amay Parikh, Lili Chan, Mary Bridgeman, Milisha Shah

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Neurologic Complications of Commonly Used Drugs in the Hospital Setting.Current neurology and neuroscience reports · 2016
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kenneth R KaufmanDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, USA ; Department of Neurology, Rutgers Robert Wood Johnson Medical School, USA ; Department of Anesthesiology, Rutgers Robert Wood Johnson Medical School, USA.
Amay ParikhDepartment of Internal Medicine, Rutgers Robert Wood Johnson Medical School, USA.
Lili ChanDepartment of Internal Medicine, Rutgers Robert Wood Johnson Medical School, USA.
Mary BridgemanDepartment of Pharmacy Practice and Administration, Rutgers Ernest Mario School of Pharmacy, USA.
Milisha ShahPharmaceutical Services, West Virginia University Healthcare, USA.
Johnson University · USRutgers, The State University of New Jersey · USWest Virginia University · US

Funding

Mount Sinai Nephrology Research Training GrantT32DK007757 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CAMPBELL, KIRK N, HE, JOHN CIJIANG · 1998 to 2022
$3.8M
NIDDK NIH HHS T32 DK007757
6 · The paper itself

Abstract

Gabapentin, an AED approved for the adjunctive treatment of partial seizures with/without secondary generalization and for the treatment of postherpetic neuralgia, is frequently used off-label for the treatment of both psychiatric and pain disorders. Since gabapentin is cleared solely by renal excretion, dosing requires consideration of the patient's renal function. Myoclonic activity may occur as a complication of gabapentin toxicity, especially with acute kidney injury or end-stage renal disease. We report 2 cases of myoclonic activity associated with gabapentin toxicity in the setting of renal disease which resolved with discontinuation of gabapentin and treatment with hemodialysis and peritoneal dialysis. As gabapentin has multiple indications and off-label uses, an understanding of myoclonus, neurotoxicity, and renal dosing is important to clinicians in multiple specialties.

Indexed as

Acute kidney injuryAntiepileptic drugDiabetic peripheral neuropathic painEducationEnd-stage renal diseaseGabapentinHemodialysisMyoclonusPeritoneal dialysisToxicity

Identifiers

PMID25667856
PMCPMC4307962
OpenAlexW2068147074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.