Evidence map›Paper›PMID 25667824›Full record

ArticleEpilepsy & behavior case reports2013

Seizure control in a patient with Dravet syndrome and cystic fibrosis.

Barbara Schmalbach, Bettina Moeller, Sarah von Spiczak, Hiltrud Muhle, Ulrich Stephani, Nicolas Lang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior case reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Barbara SchmalbachDepartment of Neurology, Christian-Albrechts-University of Kiel, Arnold-Heller-Str. 3, Haus 41, 24105 Kiel, Germany.
Bettina MoellerDepartment of Neurology, Christian-Albrechts-University of Kiel, Arnold-Heller-Str. 3, Haus 41, 24105 Kiel, Germany.
Sarah von SpiczakDepartment of Neuropediatrics, Christian-Albrechts-University of Kiel, Arnold-Heller-Str. 3, Haus 9, 24105 Kiel, Germany.
Hiltrud MuhleDepartment of Neuropediatrics, Christian-Albrechts-University of Kiel, Arnold-Heller-Str. 3, Haus 9, 24105 Kiel, Germany.
Ulrich StephaniDepartment of Neuropediatrics, Christian-Albrechts-University of Kiel, Arnold-Heller-Str. 3, Haus 9, 24105 Kiel, Germany.
Nicolas LangDepartment of Neurology, Christian-Albrechts-University of Kiel, Arnold-Heller-Str. 3, Haus 41, 24105 Kiel, Germany.
Kiel University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Satisfactory treatment of patients with Dravet syndrome (DS) is often difficult. Some success can be achieved with bromides, but cognitive side effects and disturbed vigilance may limit their use. Here, we present the case of a successfully treated patient with DS and remarkable features in the course of his disease: additionally to DS, the patient was diagnosed with cystic fibrosis (CF), another genetic channelopathy. Seizure freedom could be achieved under treatment with potassium bromide at the age of 15, but at the age of 20, adverse events made it necessary to stop bromide treatment. After conversion to valproic acid, the patient remained seizure-free, and neuropsychological tests demonstrated sustained improvement of cognition.

Indexed as

BromideCF, cystic fibrosisCFTR, cystic fibrosis transmembrane conductance regulatorCystic fibrosisDravet syndromeDS, Dravet syndromeGABA, γ-aminobutyric acidSCN1A, neuronal voltage-gated sodium channel subunit type 1SMEI, severe myoclonic epilepsy of infancyTAP, Tests of Attentional PerformanceTMT A, Trail Making Test

Identifiers

PMID25667824
PMCPMC4150651
OpenAlexW1986265355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.