ArticleBasal ganglia2014
Oscillatory Activity in Basal Ganglia and Motor Cortex in an Awake Behaving Rodent Model of Parkinson's Disease.
Article in Basal ganglia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Pallidal deep brain stimulation modulates excessive cortical high β phase amplitude coupling in Parkinson disease.Brain stimulationTrial
- Soft Neural Interfaces for Circuit-Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models.Advanced healthcare materials · 2026Article
- Cortical Intra-Layer Hypersynchronization in Levodopa-Induced Dyskinesia Mouse Model.Brain and behavior · 2025Article
- Improved control effect of pathological oscillations by using delayed feedback stimulation in neural mass model with pedunculopontine nucleus.Brain and behavior · 2023Article
- Evoked responses to single pulse electrical stimulation reveal impaired striatal excitability in a rat model of Parkinson's disease.Neurobiology of disease · 2023Article
- Early decreases in cortical mid-gamma peaks coincide with the onset of motor deficits and precede exaggerated beta build-up in rat models for Parkinson's disease.Neurobiology of disease · 2021Article
- A novel low-cost electrode for recording the local field potential of freely moving rat's brain.Translational neuroscience · 2020Article
- Cortico-Striatal Oscillations Are Correlated to Motor Activity Levels in Both Physiological and Parkinsonian Conditions.Frontiers in systems neuroscience · 2020Article
- Pallidal stimulation in Parkinson disease differentially modulates local and network β activity.Journal of neural engineering · 2018Article
- Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat.Journal of neurophysiology · 2018Article
- Movement-Modulation of Local Power and Phase Amplitude Coupling in Bilateral Globus Pallidus Interna in Parkinson Disease.Frontiers in human neuroscience · 2018Article
- The role of cortical oscillations in a spiking neural network model of the basal ganglia.PloS one · 2017Article
- Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice.Neurobiology of disease · 2016Article
- Ventral Medial Thalamic Nucleus Promotes Synchronization of Increased High Beta Oscillatory Activity in the Basal Ganglia-Thalamocortical Network of the Hemiparkinsonian Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Systems-level neurophysiological state characteristics for drug evaluation in an animal model of levodopa-induced dyskinesia.Journal of neurophysiology · 2016Article
- Subthalamic nucleus activity in the awake hemiparkinsonian rat: relationships with motor and cognitive networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Functional correlates of exaggerated oscillatory activity in basal ganglia output in hemiparkinsonian rats.Experimental neurology · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Exaggerated beta range (15-30 Hz) oscillatory activity is observed in the basal ganglia of Parkinson's disease (PD) patients during implantation of deep brain stimulation electrodes. This activity has been hypothesized to contribute to motor dysfunction in PD patients. However, it remains unclear how these oscillations develop and how motor circuits become entrained into a state of increased synchronization in this frequency range after loss of dopamine. It is also unclear whether this increase in neuronal synchronization actually plays a significant role in inducing the motor symptoms of this disorder. The hemiparkinsonian rat has emerged as a useful model for investigating relationships between loss of dopamine, increases in oscillatory activity in motor circuits and behavioral state. Chronic recordings from these animals show exaggerated activity in the high beta/low gamma range (30-35 Hz) in the dopamine cell-lesioned hemisphere. This activity is not evident when the animals are in an inattentive rest state, but it can be stably induced and monitored in the motor cortex and basal ganglia when they are engaged in an on-going activity such as treadmill walking. This review discusses data obtained from this animal model and the implications and limitations of this data for obtaining further insight into the significance of beta range activity in PD.
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Registered trials
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