Evidence map›Paper›PMID 25667660›Full record

ArticleExperimental and therapeutic medicine2015

microRNA-184 functions as tumor suppressor in renal cell carcinoma.

Zhengming Su, Duqun Chen, Yifan Li, Enpu Zhang, Zuhu Yu, Ting Chen, Zhimao Jiang, Liangchao Ni, Shangqi Yang, Yaoting Gui and 2 more

Abstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhengming SuDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Shantou University Medical College, Shantou, Guangdong 515041, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
Duqun ChenDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Yifan LiDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Enpu ZhangDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
Zuhu YuDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Ting ChenDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Shantou University Medical College, Shantou, Guangdong 515041, P.R. China.
Zhimao JiangDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
Liangchao NiDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
Shangqi YangDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
Yaoting GuiDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
Jiongxian YeDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Shantou University Medical College, Shantou, Guangdong 515041, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.
Yongqing LaiDepartment of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shanghai PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China ; Shantou University Medical College, Shantou, Guangdong 515041, P.R. China ; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding RNA molecules of approximately 22 nucleotides in length that function as post-transcriptional gene regulators. Their aberrant expression may be involved in human diseases, including cancer. Although miRNA-184 (miR-184) has been reported in other tumors, its function in renal cell carcinoma (RCC) is still unknown. The aim of the present study was to investigate the role of miR-184 in RCC. The impacts of miR-184 on cell migration, proliferation and apoptosis were evaluated using migration scratch, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assay. Our studies revealed that miR-184 mimic significantly inhibits cell migration, suppresses cell proliferation and induces renal cancer cell apoptosis

Indexed as

microRNAmiR-184renal cell carcinoma

Identifiers

PMID25667660
PMCPMC4316952

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.