Evidence map›Paper›PMID 25667632›Full record

ArticleExperimental and therapeutic medicine2015

Comparative proteomic analysis of membranous nephropathy biopsy tissues using quantitative proteomics.

Weiguo Sui, Ruohan Zhang, Jiejing Chen, Huiyan He, Zhenzhen Cui, Minglin Ou, Li Guo, Shan Cong, Wen Xue, Yong Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weiguo SuiNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China.
Ruohan ZhangNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China.
Jiejing ChenNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China.
Huiyan HeNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China.
Zhenzhen CuiNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China ; College of Life Science, Guangxi Normal University, Guilin, Guangxi 541004, P.R. China.
Minglin OuNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China.
Li GuoNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China.
Shan CongNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China.
Wen XueNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China.
Yong DaiNephrology Department, Guilin 181 Hospital, Guangxi Key Laboratory of Metabolic Disease Research, Guilin, Guangxi 541002, P.R. China ; Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen, Guangdong 518020, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults and the second leading cause of end-stage renal disease due to primary glomerulonephritis. The aim of the present study was to identify potential biomarkers of MN and further characterize these proteins by Gene Ontology (GO) analysis. Isobaric tags for relative and absolute quantification were used to compare the protein levels in tissues from MN patients and healthy individuals, and the combined samples were subsequently separated by specialized communications exchange. Mass spectrometry data acquisition was conducted using a 4800 Plus MALDI TOF/TOF tandem mass spectrometry device, and the results were subjected to statistical analysis. A total of 1,903 proteins were identified, with 423 proteins exhibiting a difference of >1.5-fold compared with the control group. Of these, 202 proteins were upregulated, while 221 proteins were downregulated. In conclusion, GO enrichment analysis revealed that the differentially expressed proteins were primarily mapped to the following GO terms: 'Immune response', 'immune effector process', 'activation of immune response' and 'positive regulation of immune system process'. The affected proteins may be associated with the pathogenesis of MN; thus, may represent candidate MN biomarkers.

Indexed as

gene ontology analysisisobaric tags for relative and absolute quantificationmembranous nephropathyproteome

Identifiers

PMID25667632
PMCPMC4316945

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