ReviewEvolutionary applications2015
Friend and foe: factors influencing the movement of the bacterium Helicobacter pylori along the parasitism-mutualism continuum.
Review in Evolutionary applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Systemic serological signatures and novel biomarker CST4 link CagA-positiveFrontiers in cellular and infection microbiology · 2026Article
- Helicobacter pylori seropositivity associates with hyperglycemia, but not obesity, in Danish children and adolescents.BMC medicine · 2024Article
- Mutualism at the leading edge: insights into the eco-evolutionary dynamics of host-symbiont communities during range expansion.Journal of mathematical biology · 2024Article
- Tolerance-conferring defensive symbionts and the evolution of parasite virulence.Evolution letters · 2023Article
- Natural foods resources and dietary ingredients for the amelioration ofFrontiers in medicine · 2023Review
- Review
- Article
- High expression of Helicobacter pylori VapD in both the intracellular environment and biopsies from gastric patients with severity.PloS one · 2020Article
- Inference from the analysis of genetic structure of Helicobacter pylori strains isolates from two paediatric patients with recurrent infection.BMC microbiology · 2019Article
- Living in Cold Blood:Frontiers in microbiology · 2019Review
- The oral microbiota: dynamic communities and host interactions.Nature reviews. Microbiology · 2018Review
- The interaction between invariant Natural Killer T cells and the mucosal microbiota.Immunology · 2018Review
- Phylogeographic diversity and mosaicism of theMobile DNA · 2018Article
- Back to the future in a petri dish: Origin and impact of resurrected microbes in natural populations.Evolutionary applications · 2018Review
- Article
- Helicobacter pylori outer membrane protein and virulence marker differences in expatriate patients.Epidemiology and infection · 2016Article
- Complete Genome Sequence of Helicobacter pylori Strain 29CaP Isolated from a Mexican Patient with Gastric Cancer.Genome announcements · 2016Article
- Diet andPrzeglad gastroenterologiczny · 2016Review
- Nutrition and Helicobacter pylori: Host Diet and Nutritional Immunity Influence Bacterial Virulence and Disease Outcome.Gastroenterology research and practice · 2016Review
- Pathogenesis of Helicobacter pylori Infection.Helicobacter · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the transition of bacterial species from commensal to pathogen, or vice versa, is a key application of evolutionary theory to preventative medicine. This requires working knowledge of the molecular interaction between hosts and bacteria, ecological interactions among microbes, spatial variation in bacterial prevalence or host life history, and evolution in response to these factors. However, there are very few systems for which such broad datasets are available. One exception is the gram-negative bacterium, Helicobacter pylori, which infects upwards of 50% of the global human population. This bacterium is associated with a wide breadth of human gastrointestinal disease, including numerous cancers, inflammatory disorders, and pathogenic infections, but is also known to confer fitness benefits to its host both indirectly, through interactions with other pathogens, and directly. Outstanding questions are therefore why, when, and how this bacterium transitions along the parasitism-mutualism continuum. We examine known virulence factors, genetic predispositions of the host, and environmental contributors that impact progression of clinical disease and help define geographical trends in disease incidence. We also highlight the complexity of the interaction and discuss future therapeutic strategies for disease management and public health in light of the longstanding evolutionary history between the bacterium and its human host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.