ArticleFrontiers in human neuroscience2015
Association between Genetic Variation in the Oxytocin Receptor Gene and Emotional Withdrawal, but not between Oxytocin Pathway Genes and Diagnosis in Psychotic Disorders.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Intranasal Oxytocin for Negative Symptoms of Schizophrenia: Systematic Review, Meta-Analysis, and Dose-Response Meta-Analysis of Randomized Controlled Trials.The international journal of neuropsychopharmacology · 2021Pooled it
- Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction.International journal of molecular sciences · 2022Review
- Measuring Affinity of Ligands to the Oxytocin Receptor Using Radioligand Binding.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank.Translational psychiatry · 2021Article
- Pharmacological Treatment for Social Cognition: Current Evidence.International journal of molecular sciences · 2021Review
- Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment.International journal of molecular sciences · 2021Review
- Brain oxytocin: how puzzle stones from animal studies translate into psychiatry.Molecular psychiatry · 2021Review
- A common variant in OXTR rs53576 impacts topological patterns of brain functional networks.European child & adolescent psychiatry · 2020Article
- A SNP, Gene, and Polygenic Risk Score Approach of Oxytocin-Vasopressin Genes in Adolescents' Loneliness.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2020Article
- [Oxytocin in schizophrenia : Evidence for an etiological and therapeutic relevance of the social neuromodulator].Der Nervenarzt · 2019Review
- Evidence for Association Between OXTR Gene and ASD Clinical Phenotypes.Journal of molecular neuroscience : MN · 2018Article
- A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder.Frontiers in molecular neuroscience · 2018Review
- Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders.Biological psychiatry · 2017Article
- Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders.BJPsych open · 2016Article
- Oxytocin ReceptorMolecular neuropsychiatry · 2016Article
- Potential of Oxytocin in the Treatment of Schizophrenia.CNS drugs · 2016Review
- ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin-Frontiers in neuroscience · 2016Article
- Oxytocin and Vasopressin Receptor Gene Polymorphisms: Role in Social and Psychiatric Traits.Frontiers in neuroscience · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social dysfunction is common in patients with psychotic disorders. Oxytocin is a neuropeptide with a central role in social behavior. This study aims to explore the relationship between oxytocin pathway genes and symptoms related to social dysfunction in patients with psychotic disorders. We performed association analyses between four oxytocin pathway genes (OXT, OXTR, AVP, and CD38) and four areas of social behavior-related psychopathology as measured by Positive and Negative Syndrome Scale. For this purpose, we used both a polygenic risk score (PGRS) and single OXTR candidate single nucleotide polymorphism previously reported in the literature (rs53576, rs237902, and rs2254298). A total of 734 subjects with DSM-IV psychotic spectrum disorders and 420 healthy controls were included. Oxytocin pathway PGRSs were calculated based on the independent Psychiatric Genomics Consortium study sample. There was a significant association between symptom of Emotional Withdrawal and the previously reported OXTR risk allele A in rs53576. No significant associations between oxytocin pathway gene variants and a diagnosis of psychotic disorder were found. Our findings indicate that while oxytocin pathway genes do not appear to contribute to the susceptibility to psychotic disorders, variations in the OXTR gene might play a role in the development of impaired social behavior.
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Registered trials
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