Evidence map›Paper›PMID 25667399›Full record

ReviewInvestigative ophthalmology & visual science2015

Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium.

Debra A Thompson, Robin R Ali, Eyal Banin, Kari E Branham, John G Flannery, David M Gamm, William W Hauswirth, John R Heckenlively, Alessandro Iannaccone, K Thiran Jayasundera and 7 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Review
  9. Genetic profile of syndromic retinitis pigmentosa in Portugal.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  10. Random Allelic Expression in Inherited Retinal Disease Genes.Current issues in molecular biology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. The Bovine Ex Vivo Retina: A Versatile Model for Retinal Neuroscience.Investigative ophthalmology & visual science · 2023
    Article
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 4 countries.

Debra A ThompsonDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States.
Robin R AliDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States Division of Molecular Therapy, University College London Institute of Ophthalmology, London, England, United Kingdom.
Eyal BaninDepartment of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Kari E BranhamDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States.
John G FlanneryHelen Wills Neuroscience Institute, University of California-Berkeley, Berkeley, California, United States.
David M GammDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
William W HauswirthDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida, United States.
John R HeckenlivelyDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States.
Alessandro IannacconeDepartment of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
K Thiran JayasunderaDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States.
Naheed W KhanDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States.
Robert S MoldayDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Mark E PennesiCasey Eye Institute and the Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, United States.
Thomas A RehDepartment of Biological Structure, University of Washington, Seattle, Washington, United States.
Richard G WeleberCasey Eye Institute and the Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, United States Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States.
David N ZacksDepartment of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States.
Monaciano Consortium
University of Michigan · USMichigan United · USOregon Health & Science University · USHadassah Medical Center · ILUniversity of British Columbia · CAUniversity of California, Berkeley · USUniversity of Florida · USUniversity of Tennessee Health Science Center · USUniversity of Washington · USUniversity of Wisconsin–Madison · US

Funding

Self Renewal and Differentiation of Human Embryonic Stem CellsP01GM081619 · NIGMS · UNIVERSITY OF WASHINGTON · PI REH, THOMAS A · 2007 to 2017
$20.6M
rAAV-CNGB3 Gene Therapy for Achromatopsia: Translational Research StudiesR24EY022023 · NEI · UNIVERSITY OF FLORIDA · PI HAUSWIRTH, WILLIAM W · 2013 to 2017
$7.9M
DNA LINKAGE STUDIES OF DEGENERATIVE RETINAL DISEASESR01EY007142 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DAIGER, STEPHEN P · 1989 to 2017
$4.1M
STRUCTURE/FUNCTION OF ROS PLASMA MEMBRANE PROTEINSR01EY002422 · NEI · UNIVERSITY OF BRITISH COLUMBIA · PI MOLDAY, ROBERT S · 1985 to 2017
$3.5M
Vision Research CoreP30EY021721 · NEI · UNIVERSITY OF FLORIDA · PI HAUSWIRTH, WILLIAM W · 2011 to 2015
$2.8M
Medical Research Council MR/J004553/1Medical Research Council MR/J005215/1Medical Research Council MR/K025589/1NEI NIH HHS P30 EY021721NEI NIH HHS R01 EY002422NEI NIH HHS R01 EY007142NEI NIH HHS R24 EY022023NIGMS NIH HHS P01 GM081619
6 · The paper itself

Abstract

Although rare in the general population, retinal dystrophies occupy a central position in current efforts to develop innovative therapies for blinding diseases. This status derives, in part, from the unique biology, accessibility, and function of the retina, as well as from the synergy between molecular discoveries and transformative advances in functional assessment and retinal imaging. The combination of these factors has fueled remarkable progress in the field, while at the same time creating complex challenges for organizing collective efforts aimed at advancing translational research. The present position paper outlines recent progress in gene therapy and cell therapy for this group of disorders, and presents a set of recommendations for addressing the challenges remaining for the coming decade. It is hoped that the formulation of these recommendations will stimulate discussions among researchers, funding agencies, industry, and policy makers that will accelerate the development of safe and effective treatments for retinal dystrophies and related diseases.

Indexed as

Disease ManagementPractice Guidelines as TopicCongresses as TopicHumansRetinal Degenerationcell therapydisease phenotypesgene therapyoutcome measuresretinal dystrophy

Identifiers

PMID25667399
PMCPMC4554258
OpenAlexW2059763304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.