ArticlePlant physiology2015
S-nitrosylation positively regulates ascorbate peroxidase activity during plant stress responses.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed.
- Modulation of GSNOR activity for improved NO homeostasis and flood resilience in plants.Plant signaling & behavior · 2026Review
- PbrIDD2-PbrAPX14 Module Functions in the Ethylene-Mediated Ripening and Senescence Process of Pear Fruit.Plant biotechnology journal · 2026Article
- Global Crotonylome Profiling Identifies TaPRXIIB Crotonylation as a Modulator HMolecular plant pathology · 2026Article
- Aboveground whole-plant live HRedox biology · 2026Article
- Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S-Nitrosylation of MEK1.Plant biotechnology journal · 2026Article
- Integration of NO and HPlant communications · 2026Review
- Peroxidase Gene CaPOD49 Suppresses Chilli Veinal Mottle Virus Infection and Increases Oxidative Stress Tolerance in Chilli Pepper.Molecular plant pathology · 2026Article
- Salicylic acid enhances photosynthesis in Borago officinalis plants exposed to water deficit by nitric oxide-mediated boosting carbonic anhydrase and antioxidant system.BMC plant biology · 2025Article
- The Central Role of GSNOR: Decoding Nitric Oxide Signaling for Crop Stress Tolerance.International journal of molecular sciences · 2025Review
- Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- In-depth investigation the size effect of zinc oxide nanostructures on the photodegradation of different dyes under UV-irradiation: anticancer application.Scientific reports · 2025Article
- Nitric Oxide and Photosynthesis Interplay in Plant Interactions with Pathogens.International journal of molecular sciences · 2025Review
- Nitric Oxide Regulates Multiple Signal Pathways in Plants via ProteinCurrent issues in molecular biology · 2025Review
- Reactive Oxygen Species in Plants: Metabolism, Signaling, and Oxidative Modifications.Antioxidants (Basel, Switzerland) · 2025Review
- Study on a Mechanism of Improving MaAPX1 Protein Activity by Mutating Methionine to Lysine.Antioxidants (Basel, Switzerland) · 2024Article
- Exogenous Sodium Nitroprusside Affects the Redox System of Wheat Roots Differentially Regulating the Activity of Antioxidant Enzymes under Short-Time Osmotic Stress.Plants (Basel, Switzerland) · 2024Article
- Biochemical and Functional Profiling of Thioredoxin-Dependent Cytosolic GPX-like Proteins inBiomolecules · 2024Article
- Crosstalk between melatonin and nitric oxide restrains Cadmium-induced oxidative stress and enhances vinblastine biosynthesis in Catharanthus roseus (L) G Don.Plant cell reports · 2024Article
- Ascorbate peroxidase in fruits and modulation of its activity by reactive species.Journal of experimental botany · 2024Review
- The ascorbate-glutathione cycle coming of age.Journal of experimental botany · 2024Review
39 more citing papers are in PubMed but not listed here.
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) and reactive oxygen species (ROS) are two classes of key signaling molecules involved in various developmental processes and stress responses in plants. The burst of NO and ROS triggered by various stimuli activates downstream signaling pathways to cope with abiotic and biotic stresses. Emerging evidence suggests that the interplay of NO and ROS plays a critical role in regulating stress responses. However, the underpinning molecular mechanism remains poorly understood. Here, we show that NO positively regulates the activity of the Arabidopsis (Arabidopsis thaliana) cytosolic ascorbate peroxidase1 (APX1). We found that S-nitrosylation of APX1 at cysteine (Cys)-32 enhances its enzymatic activity of scavenging hydrogen peroxide, leading to the increased resistance to oxidative stress, whereas a substitution mutation at Cys-32 causes the reduction of ascorbate peroxidase activity and abolishes its responsiveness to the NO-enhanced enzymatic activity. Moreover, S-nitrosylation of APX1 at Cys-32 also plays an important role in regulating immune responses. These findings illustrate a unique mechanism by which NO regulates hydrogen peroxide homeostasis in plants, thereby establishing a molecular link between NO and ROS signaling pathways.
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