Trial reportPediatrics2015
Utility of symptoms to predict treatment outcomes in obstructive sleep apnea syndrome.
Trial report in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06973928 (Is Change in Mouth Opening Related to Change in Quality of Life in Children With Type 1 Obstructive Sleep Apnea After Adenotonsillectomy? The JawChild Prospective Cohort Study), which is not on this map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is Change in Mouth Opening Related to Change in Quality of Life in Children With Type 1 Obstructive Sleep Apnea After Adenotonsillectomy? The JawChild Prospective Cohort Study
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Postoperative Bleeding and Associated Utilization following Tonsillectomy in Children.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2017Pooled it
- Pooled it
- Sleep and pulmonary outcomes for clinical trials of airway plexiform neurofibromas in NF1.Neurology · 2016Guideline
- Adenotonsillectomy for Snoring and Mild Sleep Apnea in Children: A Randomized Clinical Trial.JAMA · 2023Trial
- Cognitive parameters in children with mild obstructive sleep disordered breathing.Sleep & breathing = Schlaf & Atmung · 2021Trial
- Montelukast for Children with Obstructive Sleep Apnea: Results of a Double-Blind, Randomized, Placebo-Controlled Trial.Annals of the American Thoracic Society · 2016Trial
- Cognitive Effects of Adenotonsillectomy for Obstructive Sleep Apnea.Pediatrics · 2016Trial
- Polysomnographic versus parent-reported predictors of executive function in children with sleep disordered breathing.International journal of pediatric otorhinolaryngology · 2026Article
- Article
- Validation of the Dutch sleep-related breathing disorder scale from the pediatric sleep questionnaire: a diagnostic accuracy study using polysomnography.Sleep & breathing = Schlaf & Atmung · 2025Article
- Article
- Article
- Role of endothelial dysfunction in sleep-disordered breathing in egyptian children with sickle cell disease.BMC pediatrics · 2024Article
- Development and Validation of a Nomogram for Predicting Obstructive Sleep Apnea Severity in Children.Nature and science of sleep · 2024Article
- Performance of PROMIS Measures to Assess Fatigue and Sleep Symptom Severity Among African American Patients Newly Diagnosed With Obstructive Sleep Apnea.Clinical nursing research · 2023Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Alternatives to Polysomnography for the Diagnosis of Pediatric Obstructive Sleep Apnea.Diagnostics (Basel, Switzerland) · 2023Review
- Impact of Spina Bifida on Sleep Quality: Current Insights.Nature and science of sleep · 2023Review
- Evaluation and diagnosis of pediatric obstructive sleep apnea-An update.Frontiers in sleep · 2023Review
- Recent advances in paediatric sleep disordered breathing.Breathe (Sheffield, England) · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 13 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesPolysomnography defines the pathophysiology of obstructive sleep apnea syndrome (OSAS) but does not predict some important comorbidities or their response to adenotonsillectomy. We assessed whether OSAS symptoms, as reflected on the Sleep-Related Breathing Disorders Scale of the Pediatric Sleep Questionnaire (PSQ), may offer clinical predictive value.
methodsBaseline and 7-month follow-up data were analyzed from 185 participants (aged 5-9 years with polysomnographically confirmed OSAS) in the surgical treatment arm of the multicenter Childhood Adenotonsillectomy Trial. Associations were assessed between baseline PSQ or polysomnographic data and baseline morbidity (executive dysfunction, behavior, quality of life, sleepiness) or postsurgical improvement.
resultsAt baseline, each 1-SD increase in baseline PSQ score was associated with an adjusted odds ratio that was ∼3 to 4 times higher for behavioral morbidity, 2 times higher for reduced global quality of life, 6 times higher for reduced disease-specific quality of life, and 2 times higher for sleepiness. Higher baseline PSQ scores (greater symptom burden) also predicted postsurgical improvement in parent ratings of executive functioning, behavior, quality of life, and sleepiness. In contrast, baseline polysomnographic data did not independently predict these morbidities or their postsurgical improvement. Neither PSQ nor polysomnographic data were associated with objectively assessed executive dysfunction or improvement at follow-up.
conclusionsPSQ symptom items, in contrast to polysomnographic results, reflect subjective measures of OSAS-related impairment of behavior, quality of life, and sleepiness and predict their improvement after adenotonsillectomy. Although objective polysomnography is needed to diagnose OSAS, the symptoms obtained during an office visit can offer adjunctive insight into important comorbidities and likely surgical responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.