Evidence map›Paper›PMID 25667151›Full record

Trial reportBMJ open2015

Effectiveness of a multifactorial intervention on preventing development of frailty in pre-frail older people: study protocol for a randomised controlled trial.

Nicola Fairhall, Susan E Kurrle, Catherine Sherrington, Stephen R Lord, Keri Lockwood, Beatrice John, Noeline Monaghan, Kirsten Howard, Ian D Cameron

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Article
  7. Review
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  15. Observational
  16. Closing the Osteoporosis Care Gap.Current osteoporosis reports · 2021
    Review
  17. Effects of a Person-Centered Nursing Intervention for Frailty among Prefrail Community-Dwelling Older Adults.International journal of environmental research and public health · 2020
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nicola FairhallRehabilitation Studies Unit, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Susan E KurrleDivision of Rehabilitation and Aged Care, Hornsby Ku-ring-gai Health Service, Hornsby, New South Wales, Australia.
Catherine SherringtonThe George Institute for International Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Stephen R LordNeuroscience Research Australia, University of New South Wales, Sydney, New South Wales, Australia.
Keri LockwoodDivision of Rehabilitation and Aged Care, Hornsby Ku-ring-gai Health Service, Hornsby, New South Wales, Australia.
Beatrice JohnDivision of Rehabilitation and Aged Care, Hornsby Ku-ring-gai Health Service, Hornsby, New South Wales, Australia.
Noeline MonaghanRehabilitation Studies Unit, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Kirsten HowardSchool of Public Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Ian D CameronRehabilitation Studies Unit, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
University of Sydney · AUHornsby Ku-ring-gai Hospital · AUUNSW Sydney · AU

Funding

Medical Research Council
6 · The paper itself

Abstract

introductionFrailty is a major concern due to its costly and widespread consequences, yet evidence of effective interventions to delay or reduce frailty is lacking. Our previous study found that a multifactorial intervention was feasible and effective in reducing frailty in older people who were already frail. Identifying and treating people in the pre-frail state may be an effective means to prevent or delay frailty. This study describes a randomised controlled trial that aims to evaluate the effectiveness of a multifactorial intervention on development of frailty in older people who are pre-frail. METHODS AND ANALYSIS: A single centre randomised controlled trial with concealed allocation, assessor blinding and intention-to-treat analysis. Two hundred and thirty people aged above 70 who meet the Cardiovascular Health Study frailty criteria for pre-frailty, reside in the community and are without severe cognitive impairment will be recruited. Participants will be randomised to receive a multifactorial intervention or usual care. The intervention group will receive a 12-month interdisciplinary intervention targeting identified characteristics of frailty and problems identified during geriatric assessment. Participants will be followed for a 12-month period. Primary outcome measures will be degree of frailty measured by the number of Cardiovascular Health Study frailty criteria present, and mobility measured with the Short Physical Performance Battery. Secondary outcomes will include measures of mobility, mood and use of health and community services. ETHICS AND DISSEMINATION: The study was approved by the Northern Sydney Local Health District Health Research Ethics Committee (1207-213M). The findings will be disseminated through scientific and professional conferences, and in peer-reviewed journals. TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trials Registry: ACTRN12613000043730.

Indexed as

Frail ElderlyHealth Services for the AgedAccidental FallsAffectAgedAged, 80 and overFemaleGeriatric AssessmentHumansMaleMobility LimitationOutcome Assessment, Health CareResearch DesignResidence Characteristicsfrail elderlyGERIATRIC MEDICINErandomised trial

Identifiers

PMID25667151
PMCPMC4322196
OpenAlexW2144219499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.