Evidence map›Paper›PMID 25667056›Full record

ArticleThe American journal of tropical medicine and hygiene2015

Undifferentiated febrile illness in Kathmandu, Nepal.

Corinne N Thompson, Stuart D Blacksell, Daniel H Paris, Amit Arjyal, Abhilasha Karkey, Sabina Dongol, Abhishek Giri, Christiane Dolecek, Nick Day, Stephen Baker and 3 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02773407 (Parallel Group, Double Blinded, 1), which is not on this map. Cited by 47 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 5 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02773407 phase3completednot on this mapstarted 2016, after this paper: background citation

Parallel Group, Double Blinded, 1:1, Randomized Controlled Phase III Trial of Co-trimoxazole Versus Azithromycin for the Treatment of Undifferentiated Fever In Nepal

TypeinterventionalSponsorOxford University Clinical Research Unit, VietnamRan2016 to 2019Enrolled330ConditionsUndifferentiated Febrile IllnessArmsAzithromycin, Co-trimoxazole
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Persistent febrile illnesses in Nepal: A systematic review.The Indian journal of medical research · 2018
    Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Review
  14. Estimating the Seroprevalence of Scrub Typhus in Nepal.Pathogens (Basel, Switzerland) · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Corinne N Thompson
Stuart D Blacksell
Daniel H Paris
Amit Arjyal
Abhilasha Karkey
Sabina Dongol
Abhishek Giri
Christiane Dolecek
Nick Day
Stephen Baker
Guy Thwaites
Jeremy Farrar
Buddha Basnyat

Funding

Wellcome Trust 089276Wellcome Trust 100087
6 · The paper itself

Abstract

Undifferentiated febrile illnesses (UFIs) are common in low- and middle-income countries. We prospectively investigated the causes of UFIs in 627 patients presenting to a tertiary referral hospital in Kathmandu, Nepal. Patients with microbiologically confirmed enteric fever (218 of 627; 34.8%) randomized to gatifloxacin or ofloxacin treatment were previously reported. We randomly selected 125 of 627 (20%) of these UFI patients, consisting of 96 of 409 (23%) cases with sterile blood cultures and 29 of 218 (13%) cases with enteric fever, for additional diagnostic investigations. We found serological evidence of acute murine typhus in 21 of 125 (17%) patients, with 12 of 21 (57%) patients polymerase chain reaction (PCR)-positive for Rickettsia typhi. Three UFI cases were quantitative PCR-positive for Rickettsia spp., two UFI cases were seropositive for Hantavirus, and one UFI case was seropositive for Q fever. Fever clearance time (FCT) for rickettsial infection was 44.5 hours (interquartile range = 26-66 hours), and there was no difference in FCT between ofloxacin or gatifloxacin. Murine typhus represents an important cause of predominantly urban UFIs in Nepal, and fluoroquinolones seem to be an effective empirical treatment.

Indexed as

Anti-Bacterial AgentsFeverFluoroquinolonesGatifloxacinHumansNepalOfloxacinProspective StudiesQ FeverRickettsia InfectionsTyphoid FeverTyphus, Endemic Flea-BorneAnti-Bacterial AgentsFluoroquinolonesGatifloxacinOfloxacin

Identifiers

PMID25667056
PMCPMC4385789
OpenAlexW2154927703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.