Evidence map›Paper›PMID 25666939›Full record

Trial reportBreast cancer (Tokyo, Japan)2016

Clinicopathological predictive factors for ipsilateral and contralateral events following initial surgery to treat ductal carcinoma in situ.

Nobuko Tamura, Hitoshi Tsuda, Masayuki Yoshida, Takashi Hojo, Sadako Akashi-Tanaka, Takayuki Kinoshita, Kenichi Sugihara

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer (Tokyo, Japan), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. What does risk of future cancer mean to breast cancer patients?Breast cancer research and treatment · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Nobuko TamuraDepartment of Breast and Endocrine Surgery, Toranomon Hospital, Tokyo, Japan.
Hitoshi TsudaDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan. hstsuda@gmail.com.
Masayuki YoshidaDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
Takashi HojoBreast Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
Sadako Akashi-TanakaDivision of breast Surgical Oncology, Showa University School of Medicine, Tokyo, Japan.
Takayuki KinoshitaBreast Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
Kenichi SugiharaSurgical Oncology Division, Tokyo Medical and Dental University, Tokyo, Japan.
Tokyo National Hospital · JPShowa University · JPTokyo Medical and Dental University · JPToranomon Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIpsilateral breast tumor recurrence (IBTR) after partial breast resection and contralateral breast tumor recurrence (CBTR) have been shown to occur relatively frequently in patients with ductal carcinoma in situ (DCIS). However, there is only limited data from Japanese institutes to support this.

methodsOf 301 consecutive DCIS patients, 179 patients underwent a mastectomy, and the other 122 underwent partial resection in the National Cancer Center Hospital, Tokyo, with a median follow-up period of 2,106 days. We reviewed clinicopathological parameters including age, menopausal status, body mass index, family history (FH) of breast cancer, tumor size, histological subtype, nuclear grade (NG), hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status, treatment, and the surgical margin status of partially resected specimens. The risk associated with each of these parameters for IBTR in 122 patients who underwent partial resections, and for CBTR in a total of 301 patients were calculated using Cox proportional hazard general linear models.

resultsOf the 122 patients who underwent partial breast resection, IBTR occurred in 7 (5.7%). The risk of IBTR was higher or tended to be higher in younger patients or those with lower NG tumors, but did not change significantly with respect to margin status or irradiation. Amongst the entire cohort of 301 patients, CBTR occurred in 18 cases (6.0%). CBTR occurred significantly more frequently in patients with a FH of breast cancer and with HR+/HER2- subtype tumors by univariate analyses, and tumor subtype was an independent risk factor for CBTR by multivariate analysis.

conclusionsThe local recurrence rate was low following partial resection of DCIS. Younger age was a risk factor for IBTR, whereas the HR+/HER2- tumor subtype and a FH of breast cancer were risk factors for CBTR.

Indexed as

AdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingErb-b2 Receptor Tyrosine KinasesFemaleHumansMastectomyMastectomy, SegmentalMiddle AgedNeoplasm Recurrence, LocalPrognosisTreatment OutcomeERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesContralateral breast tumor recurrence (CBTR)Ductal carcinoma in situ (DCIS)Histological subtypeIntrinsic subtypeIspilateral breast tumor recurrence (IBTR)Nuclear grade

Identifiers

PMID25666939
PMCPMC4839035
OpenAlexW1971763992

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.