ReviewNature reviews. Gastroenterology & hepatology2015
Childhood functional abdominal pain: mechanisms and management.
Review in Nature reviews. Gastroenterology & hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 107 citations in OpenAlex.
- The association between ADHD and physical health: a co-twin control study.Scientific reports · 2020Trial
- Acceptance-based interoceptive exposure for young children with functional abdominal pain.Behaviour research and therapy · 2017Trial
- Sleep, Stress, Circadian Rhythm, and Diet in Pediatric Disorders of Gut-Brain Interaction: A Narrative Review.Nutrients · 2026Review
- Review
- Abdominal Migraine in Adults: A Narrative Review.Cureus · 2025Review
- The low FODMAP diet in adolescents functional abdominal in a non-guided setting: a prospective multicenter cohort study.European journal of pediatrics · 2025Article
- An exploratory machine learning study on paediatric abdominal pain phenotyping and prediction.PloS one · 2025Article
- Understanding functional abdominal pain disorders among children: a multidisciplinary expert consensus statement.Frontiers in pediatrics · 2025Review
- Parental Factors Associated to Functional Abdominal Pain Disorders in the Pediatric Age Group: A Case-Control Study.Advanced biomedical research · 2025Article
- Early childhood risk factors for later onset of pediatric chronic pain: a multi-method longitudinal study.BMC pediatrics · 2024Article
- Development and Evaluation of the Abdominal Pain Knowledge Questionnaire (A-PKQ) for Children and Their Parents.Children (Basel, Switzerland) · 2024Article
- Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms.Nature reviews. Neurology · 2024Review
- Probiotics in Functional Gastrointestinal Disorders.Advances in experimental medicine and biology · 2024Review
- Role of Probiotics in the Treatment and Prevention of Common Gastrointestinal Conditions in Children.Pediatric gastroenterology, hepatology & nutrition · 2024Review
- Article
- Current treatment practice of functional abdominal pain disorders in children: A multicenter survey.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Article
- Diet and Pediatric Functional Gastrointestinal Disorders in Mediterranean Countries.Nutrients · 2022Article
- Prophylactic Therapy Response in Children with Abdominal Migraine: A Single Centre Experience in Oman.Pediatric gastroenterology, hepatology & nutrition · 2022Article
- Article
- Importance of sleep quality in functional abdominal pain disorder in pediatric patients.Sleep and biological rhythms · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic abdominal pain is one of the most common clinical syndromes encountered in day to day clinical paediatric practice. Although common, its definition is confusing, predisposing factors are poorly understood and the pathophysiological mechanisms are not clear. The prevailing viewpoint in the pathogenesis involves the inter-relationship between changes in hypersensitivity and altered motility, to which several risk factors have been linked. Making a diagnosis of functional abdominal pain can be a challenge, as it is unclear which further diagnostic tests are necessary to exclude an organic cause. Moreover, large, well-performed, high-quality clinical trials for effective agents are lacking, which undermines evidence-based treatment. This Review summarizes current knowledge regarding the epidemiology, pathophysiology, risk factors and diagnostic work-up of functional abdominal pain. Finally, management options for children with functional abdominal pain are discussed including medications, dietary interventions, probiotics and psychological and complementary therapies, to improve understanding and to maximize the quality of care for children with this condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.