Evidence map›Paper›PMID 25666585›Full record

ArticleScientific reports2015

RASTtk: a modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes.

Thomas Brettin, James J Davis, Terry Disz, Robert A Edwards, Svetlana Gerdes, Gary J Olsen, Robert Olson, Ross Overbeek, Bruce Parrello, Gordon D Pusch and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,813 papers.

0numbers the graph read from it
0cells of the map it votes in
1,813citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,813 citing papers in PubMed.

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1,753 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Thomas Brettin1] Computing, Environment and Life Sciences, Argonne National Laboratory, Argonne IL, 60439, USA [2] Computation Institute, University of Chicago, Chicago, Illinois, 60637, USA.
James J Davis1] Computing, Environment and Life Sciences, Argonne National Laboratory, Argonne IL, 60439, USA [2] Computation Institute, University of Chicago, Chicago, Illinois, 60637, USA.
Terry DiszFellowship for Interpretation of Genomes, Burr Ridge, IL, 60527, USA.
Robert A Edwards1] Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA [2] Department of Computer Science, San Diego State University, San Diego, California, 92182, USA.
Svetlana Gerdes1] Computing, Environment and Life Sciences, Argonne National Laboratory, Argonne IL, 60439, USA [2] Fellowship for Interpretation of Genomes, Burr Ridge, IL, 60527, USA.
Gary J OlsenDepartment of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Robert Olson1] Computation Institute, University of Chicago, Chicago, Illinois, 60637, USA [2] Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA.
Ross Overbeek1] Computing, Environment and Life Sciences, Argonne National Laboratory, Argonne IL, 60439, USA [2] Fellowship for Interpretation of Genomes, Burr Ridge, IL, 60527, USA.
Bruce Parrello1] Computing, Environment and Life Sciences, Argonne National Laboratory, Argonne IL, 60439, USA [2] Fellowship for Interpretation of Genomes, Burr Ridge, IL, 60527, USA.
Gordon D Pusch1] Computing, Environment and Life Sciences, Argonne National Laboratory, Argonne IL, 60439, USA [2] Fellowship for Interpretation of Genomes, Burr Ridge, IL, 60527, USA.
Maulik ShuklaVirginia Bioinformatics Institute, Virginia Tech University, Blacksburg, VA, 24060, USA.
James A ThomasonUSDA-ARS Laboratory at Cold Spring Harbor Laboratory, Cold Spring Harbor NY, 11724, USA.
Rick Stevens1] Computing, Environment and Life Sciences, Argonne National Laboratory, Argonne IL, 60439, USA [2] Computation Institute, University of Chicago, Chicago, Illinois, 60637, USA [3] Department of Computer Science, University of Chicago, Chicago, Illinois, 60637, USA.
Veronika Vonstein1] Computing, Environment and Life Sciences, Argonne National Laboratory, Argonne IL, 60439, USA [2] Fellowship for Interpretation of Genomes, Burr Ridge, IL, 60527, USA.
Alice R WattamVirginia Bioinformatics Institute, Virginia Tech University, Blacksburg, VA, 24060, USA.
Fangfang Xia1] Computation Institute, University of Chicago, Chicago, Illinois, 60637, USA [2] Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA.

Funding

NIAID NIH HHS HHSN272201400027CPHS HHS HHSN272201400027C
6 · The paper itself

Abstract

The RAST (Rapid Annotation using Subsystem Technology) annotation engine was built in 2008 to annotate bacterial and archaeal genomes. It works by offering a standard software pipeline for identifying genomic features (i.e., protein-encoding genes and RNA) and annotating their functions. Recently, in order to make RAST a more useful research tool and to keep pace with advancements in bioinformatics, it has become desirable to build a version of RAST that is both customizable and extensible. In this paper, we describe the RAST tool kit (RASTtk), a modular version of RAST that enables researchers to build custom annotation pipelines. RASTtk offers a choice of software for identifying and annotating genomic features as well as the ability to add custom features to an annotation job. RASTtk also accommodates the batch submission of genomes and the ability to customize annotation protocols for batch submissions. This is the first major software restructuring of RAST since its inception.

Indexed as

SoftwareMolecular Sequence Annotation

Identifiers

PMID25666585
PMCPMC4322359

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.