Evidence map›Paper›PMID 25666507›Full record

ArticleCellular immunology2015

A single infection with Chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in ApoE deficient mice.

Rosalinda Sorrentino, Atilla Yilmaz, Katja Schubert, Timothy R Crother, Aldo Pinto, Kenichi Shimada, Moshe Arditi, Shuang Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Monocyte Chemokines Enhance Atherosclerotic Plaque Necrosis After Bacterial Kidney Infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Article
  5. Influenza and cardiovascular disease pathophysiology: strings attached.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. BioMed research international · 2018
    Article
  11. Review
  12. Forum on immunopathological diseases and therapeutics · 2016
    Article
  13. Review
  14. Review
  15. Infection and Atherosclerosis Development.Archives of medical research · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Rosalinda SorrentinoDivision of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA; Department of Pharmaceutical and Biomedical Sciences, FARMABIOMED, University of Salerno, Fisciano 84084, Italy.
Atilla YilmazDepartment of Internal Medicine I, Division of Cardiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany.
Katja SchubertDepartment of Internal Medicine I, Division of Cardiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany.
Timothy R CrotherDivision of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA.
Aldo PintoDepartment of Pharmaceutical and Biomedical Sciences, FARMABIOMED, University of Salerno, Fisciano 84084, Italy.
Kenichi ShimadaDivision of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA.
Moshe ArditiDivision of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA.
Shuang ChenDivision of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA. Electronic address: shuang.chen@cshs.org.
Cedars-Sinai Medical Center · USJena University Hospital · DEUniversity of California, Los Angeles · USUniversity of Salerno · IT

Funding

MOLECULAR PATHOGENESIS OF CHLAMYDIA-INDUCED ATHEROGENESIR01HL066436 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2001 to 2013
$3.6M
Innate Immunity and Pathogen mediated Acceleration in Vascular InflammationR01HL111483 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHEN, SHUANG · 2012 to 2016
$2.0M
NHLBI NIH HHS HL 111483NHLBI NIH HHS HL66436NHLBI NIH HHS R01 HL066436NHLBI NIH HHS R01 HL111483
6 · The paper itself

Abstract

Several studies have demonstrated a strong link between Chlamydia pneumoniae (Cp) infection and atherosclerosis progression/exacerbation. Here, we try to understand whether a single administration of Cp could exacerbate atherosclerosis. Apoe(-/-) mice were intranasally infected with Cp followed by a high fat diet. Mice were sacrificed at different time points after Cp infection to monitor the development of the atheroma. Cp infection increased lipid content in the aortic sinus of Apoe(-/-) mice starting from 8 weeks. This was associated with increased numbers of active myeloid dendritic cells and plasmacytoid DCs which were co-localized with T-cells in the atherosclerotic plaque. The serum levels of IFN-γ showed a Th1-like environment typical of atherosclerosis. In conclusion, we demonstrate that one dose of Cp could exacerbate atherosclerotic lesion development, triggering innate immune cell accumulation early on that allowed the involvement of Th1-like cells in the exacerbation of the atherosclerotic plaque at later time points.

Indexed as

AnimalsApolipoproteins EAtherosclerosisChlamydophila InfectionsChlamydophila pneumoniaeDendritic CellsDisease ProgressionInterferon-gammaLipidsMiceMice, Inbred C57BLPlaque, AtheroscleroticSinus of ValsalvaTh1 CellsApolipoproteins EInterferon-gammaLipidsAtherosclerosisC. pneumoniaeInnate immunity

Identifiers

PMID25666507
PMCPMC4391498
OpenAlexW2049716857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.