ArticleAntimicrobial agents and chemotherapy2015
Emergence of the first levofloxacin-resistant strains of Streptococcus agalactiae isolated in Italy.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Genetic Determinants and Clonal Composition of Levofloxacin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Genetic Mechanisms of Antimicrobial Non-Susceptibility to Novel Fluoroquinolone Delafloxacin Among Bulgarian Clinical Isolates ofCurrent issues in molecular biology · 2025Article
- Molecular Epidemiology of Group BInfection and drug resistance · 2023Article
- Molecular characterization and antimicrobial resistance ofIJID regions · 2022Article
- The landscape of antimicrobial resistance in the neonatal and multi-host pathogen group BFrontiers in microbiology · 2022Article
- Streptococcus agalactiae in pregnant women: serotype and antimicrobial susceptibility patterns over five years in Eastern Sicily (Italy).European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Features of Streptococcus agalactiae strains recovered from pregnant women and newborns attending different hospitals in Ethiopia.BMC infectious diseases · 2020Article
- Multidrug-ResistantMicroorganisms · 2020Article
- Endogenous endophthalmitis caused by group B streptococcus; case reports and review of 35 reported cases.BMC ophthalmology · 2020Review
- Predominance of III/ST19 and Ib/ST10 Lineages With High Multidrug Resistance in Fluoroquinolone-Resistant Group BFrontiers in microbiology · 2020Article
- Article
- Group BMicrobiology spectrum · 2019Review
- Molecular Characteristics of Group B Streptococci Isolated from Adults with Invasive Infections in Japan.Journal of clinical microbiology · 2016Article
- Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Of 901 group B streptococcus strains analyzed, 13 (1.4%) were resistant to levofloxacin (MICs of >32 μg/ml for seven isolates, 2 μg/ml for four isolates, and 1.5 μg/ml for four isolates). Mutations in the quinolone resistance-determining regions (QRDRs) of gyrase and topoisomerase IV were identified. A double mutation involving the Ser-81 change to Leu for gyrA and the Ser-79 change to Phe or to Tyr for parC was linked to a high level of fluoroquinolone resistance. In addition, two other mutational positions in parC were observed, resulting in an Asp-83-to-Tyr substitution and an Asp-83-to-Asn substitution. Different mutations were also observed in gyrB, with unknown significance. Most levofloxacin-resistant GBS strains were of serotype Ib and belonged to sequence type 19 (ST19) and clonal complex 19 (CC-19). Most of them exhibited the epsilon gene.
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