ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2015
Could tyrosine and tryptophan serve multiple roles in biological redox processes?
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Empowering Precision C-H Functionalization: Advances in Peroxygenase Engineering.Angewandte Chemie (International ed. in English) · 2026Review
- Proximal Methionine Amino Acid Residue Affects the Properties of Redox-Active Tryptophan in an Artificial Model Protein.ACS omega · 2023Article
- Tryptophan-96 in cytochrome P450 BM3 plays a key role in enzyme survival.FEBS letters · 2023Article
- Does Tyrosine ProtectThe journal of physical chemistry. B · 2022Article
- Donor-Acceptor Pyridinium Salts for Photo-Induced Electron-Transfer-Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes Using Visible Light.Journal of the American Chemical Society · 2022Article
- Functional and protective hole hopping in metalloenzymes.Chemical science · 2021Review
- Why Do Most Aromatics Fail to Support Hole Hopping in the CytochromeThe journal of physical chemistry. B · 2021Article
- Oxalate decarboxylase uses electron hole hopping for catalysis.The Journal of biological chemistry · 2021Article
- Enhancement of fast scan cyclic voltammetry detection of dopamine with tryptophan-modified electrodes.PloS one · 2020Article
- Tuning Radical Relay Residues by Proton Management Rescues Protein Electron Hopping.Journal of the American Chemical Society · 2019Article
- Structure and Function of Tryptophan-Tyrosine Dyads in Biomimetic β Hairpins.The journal of physical chemistry. B · 2019Article
- Driving Protein Conformational Changes with Light: Photoinduced Structural Rearrangement in a Heterobimetallic Oxidase.Journal of the American Chemical Society · 2018Article
- The Rise of Radicals in Bioinorganic Chemistry.Israel journal of chemistry · 2016Article
- Defusing redox bombs?Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
2 authors.
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Abstract
Single-step electron tunnelling reactions can transport charges over distances of 15-20 Åin proteins. Longer-range transfer requires multi-step tunnelling processes along redox chains, often referred to as hopping. Long-range hopping via oxidized radicals of tryptophan and tyrosine, which has been identified in several natural enzymes, has been demonstrated in artificial constructs of the blue copper protein azurin. Tryptophan and tyrosine serve as hopping way stations in high-potential charge transport processes. It may be no coincidence that these two residues occur with greater-than-average frequency in O(2)- and H(2)O(2)-reactive enzymes. We suggest that appropriately placed tyrosine and/or tryptophan residues prevent damage from high-potential reactive intermediates by reduction followed by transfer of the oxidizing equivalent to less harmful sites or out of the protein altogether.
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