ArticleAnnals of surgical oncology2015
Lateral Neck Lymph Node Characteristics Prognostic of Outcome in Patients with Clinically Evident N1b Papillary Thyroid Cancer.
Article in Annals of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Comparison of the diagnostic performances of US-guided fine needle aspiration cytology and thyroglobulin measurement for lymph node metastases in patients with differentiated thyroid carcinoma: a meta-analysis.European radiology · 2021Pooled it
- Prognostic Value of Extranodal Extension in Thyroid Cancer: A Meta-Analysis.Yonsei medical journal · 2016Pooled it
- Prediction of Treatment Response by Thyroid Bed Uptake on Post-Ablative Whole-Body Scan in Intermediate-Risk Patients with Papillary Thyroid Cancer.Diagnostics (Basel, Switzerland) · 2025Article
- Personalized risk prediction of lateral lymph node metastasis in male papillary thyroid cancer: a sex-specific model leveraging central lymph node ratio.Future oncology (London, England) · 2025Article
- The Impact of Radioactive Iodine on Disease-Specific Survival in Low-to-Intermediate Risk N1b Papillary Thyroid Carcinoma.Annals of surgical oncology · 2025Article
- Pretreatment level of circulating tumor cells is associated with lymph node metastasis in papillary thyroid carcinoma patients with ≤ 55 years old.World journal of surgical oncology · 2025Article
- Perineural Invasion in Papillary Thyroid Cancer: A Rare Indicator of Aggressive Disease.Annals of surgical oncology · 2023Article
- Article
- Effect of skip metastasis to lateral neck lymph nodes on outcome of patients with papillary thyroid carcinoma.Langenbeck's archives of surgery · 2022Article
- The number of metastatic lymph nodes optimizes staging in patients aged 55 years or older with papillary thyroid cancer.Frontiers in endocrinology · 2022Article
- Preoperative Nodal US Features for Predicting Recurrence in N1b Papillary Thyroid Carcinoma.Cancers · 2021Article
- Lymph node metastases >5 and metastatic lymph node ratio >0.30 of differentiated thyroid cancer predict response to radioactive iodine.Cancer medicine · 2021Article
- Thyroglobulin in lymph node fine-needle aspiration biopsy washout fluid. A tertiary center experience.Archive of clinical cases · 2021Article
- Management of the Neck in Well-Differentiated Thyroid Cancer.Current oncology reports · 2020Review
- miR-3619-3p promotes papillary thyroid carcinoma progression via Wnt/β-catenin pathway.Annals of translational medicine · 2019Article
- Occult Contralateral Lateral Lymph Node Metastases in Unilateral N1b Papillary Thyroid Carcinoma.World journal of surgery · 2019Article
- Risk factors for local recurrence following lateral neck dissection for papillary thyroid carcinoma.Endocrine · 2019Article
- Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage.Oncotarget · 2018Article
- Association of Lymph Node Density With Survival of Patients With Papillary Thyroid Cancer.JAMA otolaryngology-- head & neck surgery · 2018Article
- Latero-cervical lymph node metastases (N1b) represent an additional risk factor for papillary thyroid cancer outcome.Journal of endocrinological investigation · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo identify lateral lymph node (LN) characteristics predictive of outcome in papillary thyroid cancer patients with clinically evident nodal disease.
methodsA total of 438 patients with lateral neck metastases from papillary thyroid cancer were identified from an institutional database of 3,664 differentiated thyroid cancers. The number of positive LNs, size of the largest LN, number of positive LNs to total number of LNs removed (LN burden), and presence of extranodal spread (ENS) were recorded. Cutoffs for continuous variables were determined by receiver operating characteristic curves. LN variables predictive of recurrence free survival and disease-specific survival (DSS) were identified by the Kaplan-Meier method and the Cox proportional hazard model.
resultsThe median age was 41 years (range 5-86 years). The median follow-up was 65 months (range 1-332 months). Fifty-nine patients developed disease recurrence; these were local in five, regional in 40, and distant in 30 patients. Fifteen patients died of disease. Receiver operating characteristic cutoffs were >10 positive LNs and a LN burden >17 %. No lateral LN characteristics were predictive of DSS. In patients <45 years old, univariate predictors of recurrence were >10 positive nodes (p = 0.049) and LN burden >17 % (p < 0.001). In patients ≥45 years old, >10 positive nodes, LN burden >17 %, and presence of ENS were predictive of recurrence (p = 0.019, p = 0.019, and p = 0.029, respectively).
conclusionsLN burden >17 % (1 positive LN in 6 LNs removed) in the lateral neck is predictive for recurrence in patients of all ages, whereas ENS is also prognostic for recurrence in older patients.
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