ArticleJournal of materials science. Materials in medicine2015
Hierarchical polymeric scaffolds support the growth of MC3T3-E1 cells.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Continuous pore size gradient enhances zonal-specific differentiation of stem cells in an osteochondral scaffold.RSC advances · 2025Article
- Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow.SN applied sciences · 2021Article
- Recent Progress on Biodegradable Tissue Engineering Scaffolds Prepared by Thermally-Induced Phase Separation (TIPS).International journal of molecular sciences · 2021Review
- In vitro characterization of hierarchical 3D scaffolds produced by combining additive manufacturing and thermally induced phase separation.Journal of biomaterials science. Polymer edition · 2021Article
- Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory.Nature communications · 2020Article
- Bio-Fabrication: Convergence of 3D Bioprinting and Nano-Biomaterials in Tissue Engineering and Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2020Review
- I-Optimal design of poly(lactic-co-glycolic) acid/hydroxyapatite three-dimensional scaffolds produced by thermally induced phase separation.Polymer engineering and science · 2019Article
- I-Optimal Design of Hierarchical 3D Scaffolds Produced by Combining Additive Manufacturing and Thermally Induced Phase Separation.ACS applied bio materials · 2019Article
- Prospect of Stem Cells in Bone Tissue Engineering: A Review.Stem cells international · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue engineering makes use of the principles of biology and engineering to sustain 3D cell growth and promote tissue repair and/or regeneration. In this study, macro/microporous scaffold architectures have been developed using a hybrid solid freeform fabrication/thermally induced phase separation (TIPS) technique. Poly(lactic-co-glycolic acid) (PLGA) dissolved in 1,4-dioxane was used to generate a microporous matrix by the TIPS method. The 3D-bioplotting technique was used to fabricate 3D macroporous constructs made of polyethylene glycol (PEG). Embedding the PEG constructs inside the PLGA solution prior to the TIPS process and subsequent extraction of PEG following solvent removal (1,4-dioaxane) resulted in a macro/microporous structure. These hierarchical scaffolds with a bimodal pore size distribution (<50 and >300 μm) contained orthogonally interconnected macro-channels generated by the extracted PEG. The diameter of the macro-channels was varied by tuning the dispensing parameters of the 3D bioplotter. The in vitro cell culture using murine MC3T3-E1 cell line for 21 days demonstrated that these scaffolds could provide a favorable environment to support cell adhesion and growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.