ArticleJournal of materials science. Materials in medicine2015
Biofunctionalization strategies on tantalum-based materials for osseointegrative applications.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 52 citations in OpenAlex.
- Next-Generation Biomaterials for Hard Tissue Regeneration: Balancing Biofunctionality, Biomimetic Mechanics, and Antimicrobial Resistance.Materials (Basel, Switzerland) · 2026Article
- Tissue Regeneration on Implantoplasty-Treated Implants Using a Citric Acid-Collagen-Magnesium-Based Solution: An In Vitro and In Vivo Study.Biomimetics (Basel, Switzerland) · 2026Article
- Physicochemical and Mechanical Characterization of Two Self-Curing Composite Resins for Direct Provisional Prostheses.Bioengineering (Basel, Switzerland) · 2025Article
- Effect of Surface Wettability and Energy on Bacterial Adhesion to Dental Aligners: A Comparative In Vitro Study.Bioengineering (Basel, Switzerland) · 2025Article
- The Influence of the Machining Drill and Direction of Rotation on the Surfaces of Ti6Al4V Dental Implants Subjected to Implantoplasty.Journal of functional biomaterials · 2025Article
- Progress of porous tantalum surface-modified biomaterial coatings in bone tissue engineering.Journal of materials science. Materials in medicine · 2025Review
- Influence of the Sodium Titanate Crystal Size of Biomimetic Dental Implants on Osteoblastic Behavior: An In Vitro Study.Biomimetics (Basel, Switzerland) · 2025Article
- Article
- Bioactive elements manipulate bone regeneration.Biomaterials translational · 2023Review
- On-Growth and In-Growth Osseointegration Enhancement in PM Porous Ti-Scaffolds by Two Different Bioactivation Strategies: Alkali Thermochemical Treatment and RGD Peptide Coating.International journal of molecular sciences · 2022Article
- Sol-gel-assisted micro-arc oxidation synthesis and characterization of a hierarchically rough structured Ta-Sr coating for biomaterials.RSC advances · 2020Article
- Two Different Strategies to Enhance Osseointegration in Porous Titanium: Inorganic Thermo-Chemical Treatment Versus Organic Coating by Peptide Adsorption.International journal of molecular sciences · 2018Article
- [Research progress of porous tantalum in bone tissue engineering].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Review
- Enhanced repair of segmental bone defects in rabbit radius by porous tantalum scaffolds modified with the RGD peptide.Journal of materials science. Materials in medicine · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of tantalum as biomaterial for orthopedic applications is gaining considerable attention in the clinical practice because it presents an excellent chemical stability, body fluid resistance, biocompatibility, and it is more osteoconductive than titanium or cobalt-chromium alloys. Nonetheless, metallic biomaterials are commonly bioinert and may not provide fast and long-lasting interactions with surrounding tissues. The use of short cell adhesive peptides derived from the extracellular matrix has shown to improve cell adhesion and accelerate the implant's biointegration in vivo. However, this strategy has been rarely applied to tantalum materials. In this work, we have studied two immobilization strategies (physical adsorption and covalent binding via silanization) to functionalize tantalum surfaces with a cell adhesive RGD peptide. Surfaces were used untreated or activated with either HNO3 or UV/ozone treatments. The process of biofunctionalization was characterized by means of physicochemical and biological methods. Physisorption of the RGD peptide on control and HNO3-treated tantalum surfaces significantly enhanced the attachment and spreading of osteoblast-like cells; however, no effect on cell adhesion was observed in ozone-treated samples. This effect was attributed to the inefficient binding of the peptide on these highly hydrophilic surfaces, as evidenced by contact angle measurements and X-ray photoelectron spectroscopy. In contrast, activation of tantalum with UV/ozone proved to be the most efficient method to support silanization and subsequent peptide attachment, displaying the highest values of cell adhesion. This study demonstrates that both physical adsorption and silanization are feasible methods to immobilize peptides onto tantalum-based materials, providing them with superior bioactivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.